Seroatlas · Human Serome Atlas

FAAH

Fatty-acid amide hydrolase 1

Also known as: FAAH-1, FAAH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00519
Gene: FAAH
Ensembl: ENSG00000117480
Chromosome: 1
Canonical length: 579 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>O00519|FAAH
     1  MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA GLENMDRAAQ
    61  RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY VGKAWEVNKG TNCVTSYLAD
   121  CETQLSQAPR QGLLYGVPVS LKECFTYKGQ DSTLGLSLNE GVPAECDSVV VHVLKLQGAV
   181  PFVHTNVPQS MFSYDCSNPL FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG
   241  SIRFPSSFCG ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE
   301  DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK QSLEAAGHTL
   361  VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC LGDLVSILKL PQWLKGLLAF
   421  LVKPLLPRLS AFLSNMKSRS AGKLWELQHE IEVYRKTVIA QWRALDLDVV LTPMLAPALD
   481  LNAPGRATGA VSYTMLYNCL DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK
   541  KSVGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKQSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAAH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
prostate: 45 nTPM
choroid plexus: 44 nTPM
spinal cord: 43 nTPM
thyroid gland: 39 nTPM
liver: 33 nTPM

Single-cell type

late spermatids: 222 nCPM
late primary spermatocytes: 157 nCPM
enterocytes: 85 nCPM
proximal tubule cells: 62 nCPM
enteric transient amplifying cells: 60 nCPM
oligodendrocytes: 55 nCPM

Immune cell

eosinophil: 29 nTPM
plasmacytoid DC: 8.8 nTPM
myeloid DC: 8.2 nTPM
classical monocyte: 6.9 nTPM
intermediate monocyte: 1.9 nTPM
total PBMC: 1.4 nTPM

Brain region

white matter: 74 nTPM
medulla oblongata: 48 nTPM
choroid plexus: 43 nTPM
pons: 41 nTPM
cerebral cortex: 40 nTPM
spinal cord: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FAAH.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Polysubstance abuse, susceptibility to

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAAH as an antibody target. Whether an autoantibody or antibody against FAAH could matter depends on whether native FAAH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAAH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAAH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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