Seroatlas · Human Serome Atlas

F2RL3

Proteinase-activated receptor 4

Also known as: PAR4, PAR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RI0
Gene
F2RL3
Ensembl
ENSG00000127533
Chromosome
19
Canonical length
385 aa
Protein class
G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q96RI0|F2RL3
     1  MWGRLLLWPL VLGFSLSGGT QTPSVYDESG STGGGDDSTP SILPAPRGYP GQVCANDSDT
    61  LELPDSSRAL LLGWVPTRLV PALYGLVLVV GLPANGLALW VLATQAPRLP STMLLMNLAA
   121  ADLLLALALP PRIAYHLRGQ RWPFGEAACR LATAALYGHM YGSVLLLAAV SLDRYLALVH
   181  PLRARALRGR RLALGLCMAA WLMAAALALP LTLQRQTFRL ARSDRVLCHD ALPLDAQASH
   241  WQPAFTCLAL LGCFLPLLAM LLCYGATLHT LAASGRRYGH ALRLTAVVLA SAVAFFVPSN
   301  LLLLLHYSDP SPSAWGNLYG AYVPSLALST LNSCVDPFIY YYVSAEFRDK VRAGLFQRSP
   361  GDTVASKASA EGGSRGMGTH SSLLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F2RL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • lung: 33 nTPM
  • thyroid gland: 19 nTPM
  • breast: 19 nTPM
  • adipose tissue: 19 nTPM
  • kidney: 9.1 nTPM
  • pancreas: 8.7 nTPM

Single-cell type

  • platelets: 109 nCPM
  • vascular endothelial cells: 97 nCPM
  • megakaryocytes: 62 nCPM
  • lymphatic endothelial cells: 49 nCPM
  • megakaryocyte progenitors: 16 nCPM
  • epididymal principal cells: 6.9 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • neutrophil: 1.8 nTPM
  • naive B-cell: 1.6 nTPM
  • plasmacytoid DC: 1.6 nTPM
  • NK-cell: 1.5 nTPM
  • memory B-cell: 1.4 nTPM

Brain region

  • hypothalamus: 7.4 nTPM
  • cerebellum: 7.3 nTPM
  • choroid plexus: 7.1 nTPM
  • midbrain: 6.1 nTPM
  • white matter: 6.1 nTPM
  • cerebral cortex: 5.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about F2RL3.

Disease | ImmuneIEDB

Conditions an epitope on F2RL3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0
gnomAD missense Z
0.51
DepMap mean gene effect
0.19
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F2RL3 as an antibody target. Whether an autoantibody or antibody against F2RL3 could matter depends on whether native F2RL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F2RL3 is annotated at the cell surface, where native F2RL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label F2RL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/F2RL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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