Seroatlas · Human Serome Atlas

F2RL2

Proteinase-activated receptor 3

Also known as: PAR3, PAR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00254
Gene: F2RL2
Ensembl: ENSG00000164220
Chromosome: 5
Canonical length: 374 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>O00254|F2RL2
     1  MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT
    61  GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF
   121  FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS
   181  ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP
   241  DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV
   301  KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL
   361  MSKTRNHSTA YLTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F2RL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 6.4 nTPM
retina: 4.6 nTPM
breast: 3.5 nTPM
colon: 3.5 nTPM
salivary gland: 3.5 nTPM
smooth muscle: 3.5 nTPM

Single-cell type

retinal pigment epithelial cells: 17 nCPM
rod photoreceptor cells: 17 nCPM
hematopoietic stem cells: 15 nCPM
thymocytes: 14 nCPM
tuft cells: 12 nCPM
nk-cells: 9.7 nCPM

Immune cell

basophil: 10 nTPM
NK-cell: 1.1 nTPM
plasmacytoid DC: 1.1 nTPM
neutrophil: 0.9 nTPM
T-reg: 0.9 nTPM
gdT-cell: 0.7 nTPM

Brain region

thalamus: 16 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM
cerebellum: 11 nTPM
medulla oblongata: 9.5 nTPM
pons: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Protease-activated receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Protease-activated receptor 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F2RL2 as an antibody target. Whether an autoantibody or antibody against F2RL2 could matter depends on whether native F2RL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F2RL2 is annotated at the cell surface, where native F2RL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label F2RL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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