Seroatlas · Human Serome Atlas

F2R

Proteinase-activated receptor 1

Also known as: CF2R, PAR-1, PAR1, PAR1_HUMAN, TR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25116
Gene: F2R
Ensembl: ENSG00000181104
Chromosome: 5
Canonical length: 425 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>P25116|F2R
     1  MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE
    61  KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN
   121  IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA
   181  AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK
   241  EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
   301  AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS
   361  SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY
   421  KKLLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

spleen: 65 nTPM
blood vessel: 45 nTPM
skin: 43 nTPM
gallbladder: 37 nTPM
salivary gland: 29 nTPM
heart muscle: 29 nTPM

Single-cell type

platelets: 557 nCPM
megakaryocyte progenitors: 126 nCPM
hepatic stellate cells: 116 nCPM
podocytes: 108 nCPM
megakaryocytes: 99 nCPM
decidual stromal cells: 66 nCPM

Immune cell

gdT-cell: 26 nTPM
memory CD8 T-cell: 18 nTPM
naive CD8 T-cell: 13 nTPM
total PBMC: 11 nTPM
NK-cell: 7 nTPM
MAIT T-cell: 6.5 nTPM

Brain region

midbrain: 7 nTPM
medulla oblongata: 6.6 nTPM
thalamus: 5.3 nTPM
spinal cord: 5.1 nTPM
hypothalamus: 4.8 nTPM
choroid plexus: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.01
gnomAD missense Z: 1.19
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of F2R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AP2M1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F2R as an antibody target. Whether an autoantibody or antibody against F2R could matter depends on whether native F2R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F2R is annotated at the cell surface, where native F2R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label F2R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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