Seroatlas · Human Serome Atlas

F11

Coagulation factor XI

Also known as: FA11_HUMAN, FXI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P03951
Gene: F11
Ensembl: ENSG00000088926
Chromosome: 4
Canonical length: 625 aa
Protein class: Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

625 residues, UniProt reviewed canonical sequence.

>P03951|F11
     1  MIFLYQVVHF ILFTSVSGEC VTQLLKDTCF EGGDITTVFT PSAKYCQVVC TYHPRCLLFT
    61  FTAESPSEDP TRWFTCVLKD SVTETLPRVN RTAAISGYSF KQCSHQISAC NKDIYVDLDM
   121  KGINYNSSVA KSAQECQERC TDDVHCHFFT YATRQFPSLE HRNICLLKHT QTGTPTRITK
   181  LDKVVSGFSL KSCALSNLAC IRDIFPNTVF ADSNIDSVMA PDAFVCGRIC THHPGCLFFT
   241  FFSQEWPKES QRNLCLLKTS ESGLPSTRIK KSKALSGFSL QSCRHSIPVF CHSSFYHDTD
   301  FLGEELDIVA AKSHEACQKL CTNAVRCQFF TYTPAQASCN EGKGKCYLKL SSNGSPTKIL
   361  HGRGGISGYT LRLCKMDNEC TTKIKPRIVG GTASVRGEWP WQVTLHTTSP TQRHLCGGSI
   421  IGNQWILTAA HCFYGVESPK ILRVYSGILN QSEIKEDTSF FGVQEIIIHD QYKMAESGYD
   481  IALLKLETTV NYTDSQRPIC LPSKGDRNVI YTDCWVTGWG YRKLRDKIQN TLQKAKIPLV
   541  TNEECQKRYR GHKITHKMIC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCA
   601  QRERPGVYTN VVEYVDWILE KTQAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 227 nTPM

Expression across tissuesHPA

Tissue

liver: 227 nTPM
pancreas: 56 nTPM
kidney: 26 nTPM
duodenum: 16 nTPM
gallbladder: 12 nTPM
small intestine: 8.2 nTPM

Single-cell type

hepatocytes: 134 nCPM
distal convoluted tubule cells: 47 nCPM
loop of henle epithelial cells: 43 nCPM
pancreatic acinar cells: 23 nCPM
proximal tubule cells: 18 nCPM
pdcs: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.1 nTPM
midbrain: 1.6 nTPM
thalamus: 1.6 nTPM
basal ganglia: 1.2 nTPM
amygdala: 1.1 nTPM
hippocampal formation: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about F11.

Disease | AllUniProt

Conditions F11 is implicated in, by any mechanism.

Factor XI deficiency (FA11D) MIM:612416

Disease | GeneticClinVar

220 pathogenic / likely-pathogenic of 803 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hereditary factor XI deficiency disease
Plasma factor XI deficiency
F11-related disorder
Abnormal bleeding
Factor XI deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F11 as an antibody target. Whether an autoantibody or antibody against F11 could matter depends on whether native F11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F11 is annotated as secreted, so native F11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label F11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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