Seroatlas · Human Serome Atlas

EXTL2

Exostosin-like 2

Also known as: EXTL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBQ6
Gene
EXTL2
Ensembl
ENSG00000162694
Chromosome
1
Canonical length
330 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables alpha-1,4-N-acetylgalactosaminyltransferase activity and glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in N-acetylglucosamine metabolic process and UDP-N-acetylgalactosamine metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q9UBQ6|EXTL2
     1  MRCCHICKLP GRVMGIRVLR LSLVVILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK
    61  STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIVVWN NIGEKAPDEL WNSLGPHPIP
   121  VIFKQQTANR MRNRLQVFPE LETNAVLMVD DDTLISTPDL VFAFSVWQQF PDQIVGFVPR
   181  KHVSTSSGIY SYGSFEMQAP GSGNGDQYSM VLIGASFFNS KYLELFQRQP AAVHALIDDT
   241  QNCDDIAMNF IIAKHIGKTS GIFVKPVNMD NLEKETNSGY SGMWHRAEHA LQRSYCINKL
   301  VNIYDSMPLR YSNIMISQFG FPYANYKRKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXTL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 23 nTPM
  • adrenal gland: 23 nTPM
  • ovary: 22 nTPM
  • cerebral cortex: 20 nTPM
  • basal ganglia: 18 nTPM
  • endometrium: 17 nTPM

Single-cell type

  • cytotrophoblasts: 304 nCPM
  • migrating cytotrophoblasts: 158 nCPM
  • choroid plexus epithelial cells: 123 nCPM
  • ependymal cells: 85 nCPM
  • syncytiotrophoblasts: 81 nCPM
  • adrenal cortex cells: 77 nCPM

Immune cell

  • plasmacytoid DC: 4.6 nTPM
  • NK-cell: 3.9 nTPM
  • gdT-cell: 3.4 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • memory CD8 T-cell: 2.3 nTPM
  • basophil: 2 nTPM

Brain region

  • choroid plexus: 36 nTPM
  • thalamus: 33 nTPM
  • cerebral cortex: 30 nTPM
  • hypothalamus: 28 nTPM
  • midbrain: 27 nTPM
  • basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXTL2 as an antibody target. Whether an autoantibody or antibody against EXTL2 could matter depends on whether native EXTL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXTL2 is annotated as secreted, so native EXTL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EXTL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXTL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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