EXOC1L
Exocyst complex component 1-like
Also known as: EXC1L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GW35
- Gene
- EXOC1L
- Ensembl
- ENSG00000250821
- Chromosome
- 4
- Canonical length
- 172 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for EXOC1L in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>A0A1B0GW35|EXOC1L
1 MSSLVKEDLE KKLFKPLSQN LYEFIEIEFS VQDRYYLCVS VTKKEEVKIV MVKHYRIGLD
61 EKYEVTKKWS LNDLQMIDGK EADTDNPFFD LHFKKVYSLE AYSCASKYAF ARTVNKLNHA
121 YLKKDLQIVN FDSTYINDDS IWSSNNKDCL VLMRICFYAF NLVCLSLCPL PLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EXOC1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 0.4 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 0.4 nTPM
- hypothalamus: 0.2 nTPM
- adipose tissue: 0.1 nTPM
- amygdala: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
Single-cell type
- early spermatids: 12 nCPM
- late spermatids: 8.9 nCPM
- retinal pigment epithelial cells: 4.3 nCPM
- adipocytes: 2.1 nCPM
- lactotrophs: 1.3 nCPM
- brain inhibitory neurons: 0.9 nCPM
Immune cell
- NK-cell: 1.9 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- midbrain: 0.8 nTPM
- pons: 0.6 nTPM
- spinal cord: 0.5 nTPM
- medulla oblongata: 0.3 nTPM
- thalamus: 0.3 nTPM
- amygdala: 0.2 nTPM
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EXOC1L as an antibody target. Whether an autoantibody or antibody against EXOC1L could matter depends on whether native EXOC1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EXOC1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EXOC1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...