Seroatlas · Human Serome Atlas

EVX1

Homeobox even-skipped homolog protein 1

Also known as: EVX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49640
Gene: EVX1
Ensembl: ENSG00000106038
Chromosome: 7
Canonical length: 407 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>P49640|EVX1
     1  MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER
    61  GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY
   121  EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNGGSGGGG SQGTLACSAS
   181  DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR
   241  QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF
   301  SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL ACHSGPANGL
   361  APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR EEVPLTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

prostate: 3.8 nTPM
vagina: 3.4 nTPM
adrenal gland: 2.8 nTPM
seminal vesicle: 2.8 nTPM
urinary bladder: 2.8 nTPM
cervix: 2.1 nTPM

Single-cell type

late spermatids: 110 nCPM
early spermatids: 76 nCPM
prostatic club cells: 16 nCPM
prostatic hillock cells: 8.5 nCPM
late primary spermatocytes: 8.4 nCPM
urothelial cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 3.4 nTPM
pons: 2 nTPM
spinal cord: 1.1 nTPM
white matter: 1 nTPM
cerebellum: 0.5 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.81
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

embryo development ending in birth or egg hatching
interneuron migration
positive regulation of transcription by RNA polymerase II
regulation of transcription by RNA polymerase II
ventral spinal cord interneuron specification
spinal cord interneuron axon guidance

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVX1 as an antibody target. Whether an autoantibody or antibody against EVX1 could matter depends on whether native EVX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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