Seroatlas · Human Serome Atlas

EVPLL

Envoplakin-like protein

Also known as: EVPLL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MZ36
Gene: EVPLL
Ensembl: ENSG00000214860
Chromosome: 17
Canonical length: 301 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be involved in intermediate filament cytoskeleton organization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>A8MZ36|EVPLL
     1  MQASADQVER DILETQKRLQ QDRLNSEQSQ ALQHQQETGS SLKEAEVLLK DLFLDVDKAR
    61  RLKHPQAEET EKDIEQLHER VTQECAEYCA LYEKMVLPPR RGIQGRLGTR AGAETEAGLR
   121  RPVWAGHGGA GGTDRGAQHR AEGDQRPRRA AAEPGGAGCR HHPEPIPRPT EGGVVARAEP
   181  GQPVHALQGC TWQLSALAEQ QRRILQQDWS DLMADPAGVR REYEHFKQHE LLSQEQSVNQ
   241  LEEDGKRMVE LRHPAVGPIQ AHQEALKMEW QNFLNLCICQ ETQLQHVEDY SRILCPSSSP
   301  H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVPLL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

esophagus: 17 nTPM
vagina: 8.6 nTPM
cervix: 7.3 nTPM
skin: 6 nTPM
liver: 2.6 nTPM
urinary bladder: 2.6 nTPM

Single-cell type

papillary tip epithelial cells: 11 nCPM
renal collecting duct principal cells: 6.7 nCPM
renal connecting tubule cells: 2.9 nCPM
proximal tubule cells: 1.8 nCPM
loop of henle epithelial cells: 1.7 nCPM
renal collecting duct intercalated cells: 1.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intermediate filament cytoskeleton organization

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVPLL as an antibody target. Whether an autoantibody or antibody against EVPLL could matter depends on whether native EVPLL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVPLL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVPLL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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