Seroatlas · Human Serome Atlas

EVI2B

Protein EVI2B

Also known as: CD361, D17S376, EVDB, EVI2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P34910
Gene: EVI2B
Ensembl: ENSG00000185862
Chromosome: 17
Canonical length: 448 aa
Protein class: CD markers, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Involved in positive regulation of granulocyte differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>P34910|EVI2B
     1  MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT
    61  QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA
   121  VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS
   181  TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG
   241  RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED
   301  SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ ESNQSDKPTM
   361  TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE
   421  IQCQEFSIPP NSDQDLNESL PPPPAELL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVI2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 179 nTPM
tonsil: 159 nTPM
spleen: 150 nTPM
lymph node: 149 nTPM
appendix: 95 nTPM
thymus: 71 nTPM

Single-cell type

neutrophils: 1,774 nCPM
kupffer cells: 470 nCPM
monocytes: 449 nCPM
neutrophil progenitors: 350 nCPM
monocyte progenitors: 210 nCPM
macrophages: 188 nCPM

Immune cell

neutrophil: 1,371 nTPM
basophil: 1,009 nTPM
eosinophil: 801 nTPM
non-classical monocyte: 384 nTPM
classical monocyte: 329 nTPM
total PBMC: 251 nTPM

Brain region

medulla oblongata: 24 nTPM
white matter: 19 nTPM
pons: 18 nTPM
choroid plexus: 15 nTPM
thalamus: 14 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.06
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

myeloid cell development
negative regulation of apoptotic process
positive regulation of granulocyte differentiation
regulation of cell cycle
regulation of stem cell division
positive regulation of neutrophil differentiation

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Protein EVI2B

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVI2B as an antibody target. Whether an autoantibody or antibody against EVI2B could matter depends on whether native EVI2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVI2B is annotated at the cell surface, where native EVI2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EVI2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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