Seroatlas · Human Serome Atlas

EVI2A

Protein EVI2A

Also known as: EVDA, EVI2, EVI2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22794
Gene: EVI2A
Ensembl: ENSG00000126860
Chromosome: 17
Canonical length: 236 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane,Primary cilium,Primary cilium transition zone,Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Located in several cellular components, including Golgi apparatus; cilium; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>P22794|EVI2A
     1  MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK TGRNQNENIN
    61  TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV SNSPSTVQSI ENTSKSHGEI
   121  FKKDVCAENN NNMAMLICLI IIAVLFLICT FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN
   181  GDFLASGLWP AESDTWKRTK QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVI2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 165 nTPM
thymus: 98 nTPM
midbrain: 91 nTPM
hippocampal formation: 81 nTPM
basal ganglia: 63 nTPM
lymph node: 50 nTPM

Single-cell type

oligodendrocytes: 74 nCPM
neutrophils: 69 nCPM
cardiomyocytes: 45 nCPM
t-cells: 27 nCPM
nk-cells: 26 nCPM
monocytes: 25 nCPM

Immune cell

neutrophil: 178 nTPM
total PBMC: 95 nTPM
classical monocyte: 91 nTPM
myeloid DC: 63 nTPM
T-reg: 61 nTPM
naive CD4 T-cell: 61 nTPM

Brain region

white matter: 226 nTPM
medulla oblongata: 134 nTPM
basal ganglia: 127 nTPM
cerebellum: 113 nTPM
pons: 101 nTPM
midbrain: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ectropic viral integration site 2A protein
Ectropic viral integration site 2A protein (EVI2A)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVI2A as an antibody target. Whether an autoantibody or antibody against EVI2A could matter depends on whether native EVI2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVI2A is annotated at the cell surface, where native EVI2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EVI2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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