Seroatlas · Human Serome Atlas

EVA1C

Protein eva-1 homolog C

Also known as: B18, B19, C21orf63, C21orf64, EVA1C_HUMAN, FAM176C, PRED34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58658
Gene: EVA1C
Ensembl: ENSG00000166979
Chromosome: 21
Canonical length: 441 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables heparin binding activity. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>P58658|EVA1C
     1  MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT DFSGYLTKLL
    61  QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ KPASQREDSL TCVAATTFQK
   121  VLDECQNQRA CHLLVNSRVF GPDLCPGSSK YLLVSFKCQP NELKNKTVCE DQELKLHCHE
   181  SKFLNIYSAT YGRRTQERDI CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH
   241  FGSPCLPGVK KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK
   301  DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD FRDLQLGREQ
   361  LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI YSSIEAAELA ERIERREQII
   421  QEIWMNSGLD TSLPRNMGQF Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVA1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 31 nTPM
endometrium: 26 nTPM
fallopian tube: 26 nTPM
breast: 25 nTPM
prostate: 24 nTPM
blood vessel: 23 nTPM

Single-cell type

vascular endothelial cells: 443 nCPM
respiratory ciliated cells: 420 nCPM
late spermatids: 413 nCPM
respiratory secretory cells: 410 nCPM
fallopian tube ciliated cells: 355 nCPM
salivary acinar cells: 329 nCPM

Immune cell

MAIT T-cell: 3.8 nTPM
memory CD4 T-cell: 3.2 nTPM
memory CD8 T-cell: 3.2 nTPM
NK-cell: 3.2 nTPM
gdT-cell: 3.1 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

thalamus: 7.4 nTPM
white matter: 7.3 nTPM
medulla oblongata: 6.4 nTPM
hypothalamus: 6.3 nTPM
pons: 6.1 nTPM
basal ganglia: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVA1C as an antibody target. Whether an autoantibody or antibody against EVA1C could matter depends on whether native EVA1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVA1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVA1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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