Seroatlas · Human Serome Atlas

EVA1A

Protein eva-1 homolog A

Also known as: EVA1A_HUMAN, FAM176A, FLJ13391, TMEM166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8M9
Gene: EVA1A
Ensembl: ENSG00000115363
Chromosome: 2
Canonical length: 152 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including TOR signaling; cardiac left ventricle morphogenesis; and connective tissue replacement. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q9H8M9|EVA1A
     1  MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL AALVIRISCH
    61  TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH RRFERTLNKN VFTSAEELER
   121  AQRLEERERI IREIWMNGQP EVPGTRSLNR YY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVA1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

liver: 179 nTPM
pancreas: 22 nTPM
lung: 20 nTPM
kidney: 19 nTPM
placenta: 16 nTPM
spleen: 10 nTPM

Single-cell type

syncytiotrophoblasts: 209 nCPM
proximal tubule cells: 201 nCPM
hepatocytes: 99 nCPM
alveolar cells type 1: 85 nCPM
pancreatic acinar cells: 84 nCPM
cytotrophoblasts: 72 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 2.3 nTPM
basal ganglia: 1.6 nTPM
thalamus: 1.5 nTPM
white matter: 1.5 nTPM
pons: 1.4 nTPM
spinal cord: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0.07
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVA1A as an antibody target. Whether an autoantibody or antibody against EVA1A could matter depends on whether native EVA1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVA1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVA1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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