Seroatlas · Human Serome Atlas

ETNK2

Ethanolamine kinase 2

Also known as: EKI2, EKI2_HUMAN, FLJ10761

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVF9
Gene: ETNK2
Ensembl: ENSG00000143845
Chromosome: 1
Canonical length: 386 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9NVF9|ETNK2
     1  MAVPPSAPQP RASFHLRRHT PCPQCSWGME EKAAASASCR EPPGPPRAAA VAYFGISVDP
    61  DDILPGALRL IQELRPHWKP EQVRTKRFTD GITNKLVACY VEEDMQDCVL VRVYGERTEL
   121  LVDRENEVRN FQLLRAHSCA PKLYCTFQNG LCYEYMQGVA LEPEHIREPR LFRLIALEMA
   181  KIHTIHANGS LPKPILWHKM HNYFTLVKNE INPSLSADVP KVEVLERELA WLKEHLSQLE
   241  SPVVFCHNDL LCKNIIYDSI KGHVRFIDYE YAGYNYQAFD IGNHFNEFAG VNEVDYCLYP
   301  ARETQLQWLH YYLQAQKGMA VTPREVQRLY VQVNKFALAS HFFWALWALI QNQYSTIDFD
   361  FLRYAVIRFN QYFKVKPQAS ALEMPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETNK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

liver: 220 nTPM
testis: 119 nTPM
kidney: 100 nTPM
choroid plexus: 44 nTPM
blood vessel: 30 nTPM
epididymis: 28 nTPM

Single-cell type

late spermatids: 2,339 nCPM
early spermatids: 512 nCPM
hepatocytes: 248 nCPM
late primary spermatocytes: 111 nCPM
suprabasal keratinocytes: 84 nCPM
proximal tubule cells: 80 nCPM

Immune cell

gdT-cell: 2.2 nTPM
MAIT T-cell: 2.1 nTPM
naive CD8 T-cell: 1.6 nTPM
memory CD8 T-cell: 1.3 nTPM
naive CD4 T-cell: 1.3 nTPM
NK-cell: 0.8 nTPM

Brain region

choroid plexus: 53 nTPM
hypothalamus: 25 nTPM
midbrain: 22 nTPM
amygdala: 20 nTPM
basal ganglia: 19 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETNK2 as an antibody target. Whether an autoantibody or antibody against ETNK2 could matter depends on whether native ETNK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETNK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETNK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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