ETNK1
Ethanolamine kinase 1
Also known as: EKI, EKI1, EKI1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HBU6
- Gene
- ETNK1
- Ensembl
- ENSG00000139163
- Chromosome
- 12
- Canonical length
- 452 aa
- Protein class
- Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cytosol
OverviewNCBI Gene
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
452 residues, UniProt reviewed canonical sequence.
>Q9HBU6|ETNK1
1 MLCGRPRSSS DNRNFLRERA GLSSAAVQTR IGNSAASRRS PAARPPVPAP PALPRGRPGT
61 EGSTSLSAPA VLVVAVAVVV VVVSAVAWAM ANYIHVPPGS PEVPKLNVTV QDQEEHRCRE
121 GALSLLQHLR PHWDPQEVTL QLFTDGITNK LIGCYVGNTM EDVVLVRIYG NKTELLVDRD
181 EEVKSFRVLQ AHGCAPQLYC TFNNGLCYEF IQGEALDPKH VCNPAIFRLI ARQLAKIHAI
241 HAHNGWIPKS NLWLKMGKYF SLIPTGFADE DINKRFLSDI PSSQILQEEM TWMKEILSNL
301 GSPVVLCHND LLCKNIIYNE KQGDVQFIDY EYSGYNYLAY DIGNHFNEFA GVSDVDYSLY
361 PDRELQSQWL RAYLEAYKEF KGFGTEVTEK EVEILFIQVN QFALASHFFW GLWALIQAKY
421 STIEFDFLGY AIVRFNQYFK MKPEVTALKV PELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ETNK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- stomach: 43 nTPM
- colon: 26 nTPM
- duodenum: 22 nTPM
- thymus: 22 nTPM
- epididymis: 19 nTPM
- kidney: 17 nTPM
Single-cell type
- foveolar cells: 671 nCPM
- early spermatids: 450 nCPM
- kupffer cells: 318 nCPM
- lactotrophs: 252 nCPM
- mucous neck cells: 234 nCPM
- sertoli cells: 226 nCPM
Immune cell
- basophil: 44 nTPM
- non-classical monocyte: 24 nTPM
- memory B-cell: 22 nTPM
- intermediate monocyte: 22 nTPM
- T-reg: 21 nTPM
- total PBMC: 19 nTPM
Brain region
- hypothalamus: 93 nTPM
- choroid plexus: 68 nTPM
- white matter: 68 nTPM
- pons: 68 nTPM
- cerebral cortex: 65 nTPM
- midbrain: 64 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.36
- gnomAD pLI
- 0.93
- gnomAD missense Z
- 1.91
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ETNK1 as an antibody target. Whether an autoantibody or antibody against ETNK1 could matter depends on whether native ETNK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ETNK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ETNK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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