ETFBKMT

Protein identityUniProt · HPA

UniProt accession

Q8IXQ9

Gene

ETFBKMT

Ensembl

ENSG00000139160

Chromosome

12

Canonical length

262 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrial matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8IXQ9|ETFBKMT
     1  MALSLGWKAH RNHCGLLLQA LRSSGLLLFP CGQCPWRGAG SFLDPEIKAF LEENTEVTSS
    61  GSLTPEIQLR LLTPRCKFWW ERADLWPHSD PYWAIYWPGG QALSRYLLDN PDVVRGKSVL
   121  DLGSGCGATA IAAKMSGASR ILANDIDPIA GMAITLNCEL NRLNPFPILI QNILNLEQDK
   181  WDLVVLGDMF YDEDLADSLH QWLKKCFWTY RTRVLIGDPG RPQFSGHSIQ HHLHKVVEYS
   241  LLESTRQENS GLTTSTVWGF QP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETFBKMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

9.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.76

gnomAD pLI

0

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• methylation
• negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase

Molecular functions

• heat shock protein binding
• protein-lysine N-methyltransferase activity

Cellular components

• cytoplasm
• mitochondrial matrix
• mitochondrion
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• S-adenosyl-L-methionine-dependent methyltransferase superfamily
• Ribosomal protein L11 methyltransferase (PrmA)
• Ribosomal protein L11 methyltransferase PrmA

KeywordsUniProt

• Cytoplasm
• Methyltransferase
• Mitochondrion
• Transferase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of ETFBKMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HSPD1