ETDC
Embryonic testis differentiation protein homolog C
Also known as: ETDC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GVM5
- Gene
- ETDC
- Ensembl
- ENSG00000283644
- Chromosome
- X
- Canonical length
- 59 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for ETDC in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
59 residues, UniProt reviewed canonical sequence.
>A0A1B0GVM5|ETDC
1 MDKELPKASP SEPALNIKKS GKSFKCKKPT KNVQVFLINR QLGRNRSDTD LSKWLWMLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ETDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- skin: 1 nTPM
- bone marrow: 0.7 nTPM
- seminal vesicle: 0.7 nTPM
- thyroid gland: 0.4 nTPM
- colon: 0.3 nTPM
- liver: 0.3 nTPM
Single-cell type
- cardiomyocytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 8.6 nTPM
- choroid plexus: 7.6 nTPM
- white matter: 6.9 nTPM
- midbrain: 6.3 nTPM
- pons: 5.8 nTPM
- hypothalamus: 5.5 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ETDC as an antibody target. Whether an autoantibody or antibody against ETDC could matter depends on whether native ETDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ETDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ETDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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