ETDB
Embryonic testis differentiation protein homolog B
Also known as: ETDB_HUMAN, LINC00633
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DPP9
- Gene
- ETDB
- Ensembl
- ENSG00000224107
- Chromosome
- X
- Canonical length
- 59 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for ETDB in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
59 residues, UniProt reviewed canonical sequence.
>P0DPP9|ETDB
1 MDKEVPKGSP REPALNIKKS DKSFKRKKPT ENVLIFLINR QLGRHRSDID LSRWVWMLSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ETDB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- testis: 11 nTPM
- bone marrow: 0.3 nTPM
- basal ganglia: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
- amygdala: 0.1 nTPM
Single-cell type
- early spermatids: 17 nCPM
- late primary spermatocytes: 15 nCPM
- late spermatids: 2.1 nCPM
- endometrial ciliated cells: 0.6 nCPM
- fallopian tube ciliated cells: 0.5 nCPM
- sertoli cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.1 nTPM
- basal ganglia: 0.8 nTPM
- hypothalamus: 0.7 nTPM
- pons: 0.6 nTPM
- thalamus: 0.6 nTPM
- amygdala: 0.5 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ETDB as an antibody target. Whether an autoantibody or antibody against ETDB could matter depends on whether native ETDB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ETDB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ETDB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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