Seroatlas · Human Serome Atlas

ETDA

Embryonic testis differentiation protein homolog A

Also known as: ETDA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3ZM63
Gene
ETDA
Ensembl
ENSG00000238210
Chromosome
X
Canonical length
59 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ETDA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

59 residues, UniProt reviewed canonical sequence.

>Q3ZM63|ETDA
     1  MDKEVPKGSP REPALNIKKS DKSFKRKKPT ENVLIFLINR QLGRHRSDID LSRWVWMLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • skin: 0.6 nTPM
  • bone marrow: 0.3 nTPM
  • adrenal gland: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Single-cell type

  • late primary spermatocytes: 53 nCPM
  • early spermatids: 50 nCPM
  • late spermatids: 4.4 nCPM
  • sertoli cells: 1.1 nCPM
  • endometrial ciliated cells: 1 nCPM
  • fallopian tube ciliated cells: 0.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 2 nTPM
  • amygdala: 1.7 nTPM
  • cerebral cortex: 1.7 nTPM
  • basal ganglia: 1.6 nTPM
  • thalamus: 1.6 nTPM
  • hypothalamus: 1.3 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETDA as an antibody target. Whether an autoantibody or antibody against ETDA could matter depends on whether native ETDA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETDA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETDA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ETDA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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