Seroatlas · Human Serome Atlas

ESRG

Embryonic stem cell-related gene protein

Also known as: ESRG_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q1W209
Gene: ESRG
Canonical length: 222 aa

OverviewNCBI Gene

No narrative summary is available for ESRG in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q1W209|ESRG
     1  MTLFSDSARL HPGEINSLVA HTKPVWWSLH TDAHEIWCRD SDRGTSLGRS IPCPPALCSV
    61  RKIHLRPQVL RPTSPRNISP ISNPVSGLFL LCSPTSLTIP QPLSPFNLGA TLQSLPSLNF
   121  NSFHSLVETK ETCFIREPKT PAPVTDWEGS LPLVFNHCRD ASLISRFRPR RDACLGPSPL
   181  AASPAFLGQG QVPLNPFSFT LSGKSRFSGA GASTPQPLLL HP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESRG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ESRG as an antibody target. Whether an autoantibody or antibody against ESRG could matter depends on whether native ESRG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ESRG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ESRG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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