ESM1
Endothelial cell-specific molecule 1
Also known as: ESM1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NQ30
- Gene
- ESM1
- Ensembl
- ENSG00000164283
- Chromosome
- 5
- Canonical length
- 184 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Vesicles
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Canonical amino-acid sequenceUniProt
184 residues, UniProt reviewed canonical sequence.
>Q9NQ30|ESM1
1 MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD CGCCRVCAAG
61 RGETCYRTVS GMDGMKCGPG LRCQPSNGED PFGEEFGICK DCPYGTFGMD CRETCNCQSG
121 ICDRGTGKCL KFPFFQYSVT KSSNRFVSLT EHDMASGDGN IVREEVVKEN AAGSPVMRKW
181 LNPRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ESM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- kidney: 19 nTPM
- thyroid gland: 16 nTPM
- lung: 11 nTPM
- salivary gland: 5.9 nTPM
- parathyroid gland: 5.7 nTPM
- adrenal gland: 4 nTPM
Single-cell type
- vascular endothelial cells: 37 nCPM
- salivary ionocytes: 17 nCPM
- salivary acinar cells: 17 nCPM
- salivary duct cells: 16 nCPM
- epididymal clear cells: 16 nCPM
- platelets: 7.1 nCPM
Immune cell
- NK-cell: 1.4 nTPM
- memory CD4 T-cell: 0.8 nTPM
- memory CD8 T-cell: 0.5 nTPM
- MAIT T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.4 nTPM
- gdT-cell: 0.1 nTPM
Brain region
- hypothalamus: 2.9 nTPM
- cerebral cortex: 2 nTPM
- thalamus: 1.5 nTPM
- choroid plexus: 1.3 nTPM
- spinal cord: 1.3 nTPM
- basal ganglia: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.9
- gnomAD pLI
- 0.21
- gnomAD missense Z
- 0.98
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- angiogenesis
- positive regulation of cell population proliferation
- sprouting angiogenesis
- positive regulation of hepatocyte growth factor receptor signaling pathway
Molecular functions
- extracellular matrix structural constituent
- hepatocyte growth factor receptor binding
- integrin binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ESM1 as an antibody target. Whether an autoantibody or antibody against ESM1 could matter depends on whether native ESM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ESM1 is annotated as secreted, so native ESM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ESM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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