Seroatlas · Human Serome Atlas

ESCO1

N-acetyltransferase ESCO1

Also known as: EFO1, ESCO1_HUMAN, ESO1, KIAA1911

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5FWF5
Gene: ESCO1
Ensembl: ENSG00000141446
Chromosome: 18
Canonical length: 840 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity; protein-lysine-acetyltransferase activity; and zinc ion binding activity. Involved in peptidyl-lysine acetylation; post-translational protein acetylation; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

840 residues, UniProt reviewed canonical sequence.

>Q5FWF5|ESCO1
     1  MMSIQEKSKE NSSKVTKKSD DKNSETEIQD SQKNLAKKSG PKETIKSQAK SSSESKINQP
    61  ELETRMSTRS SKAASNDKAT KSINKNTVTV RGYSQESTKK KLSQKKLVHE NPKANEQLNR
   121  RSQRLQQLTE VSRRSLRSRE IQGQVQAVKQ SLPPTKKEQC SSTQSKSNKT SQKHVKRKVL
   181  EVKSDSKEDE NLVINEVINS PKGKKRKVEH QTACACSSQC TQGSEKCPQK TTRRDETKPV
   241  PVTSEVKRSK MATSVVPKKN EMKKSVHTQV NTNTTLPKSP QPSVPEQSDN ELEQAGKSKR
   301  GSILQLCEEI AGEIESDNVE VKKESSQMES VKEEKPTEIK LEETSVERQI LHQKETNQDV
   361  QCNRFFPSRK TKPVKCILNG INSSAKKNSN WTKIKLSKFN SVQHNKLDSQ VSPKLGLLRT
   421  SFSPPALEMH HPVTQSTFLG TKLHDRNITC QQEKMKEINS EEVKINDITV EINKTTERAP
   481  ENCHLANEIK PSDPPLDNQM KHSFDSASNK NFSQCLESKL ENSPVENVTA ASTLLSQAKI
   541  DTGENKFPGS APQQHSILSN QTSKSSDNRE TPRNHSLPKC NSHLEITIPK DLKLKEAEKT
   601  DEKQLIIDAG QKRFGAVSCN VCGMLYTASN PEDETQHLLF HNQFISAVKY VGWKKERILA
   661  EYPDGRIIMV LPEDPKYALK KVDEIREMVD NDLGFQQAPL MCYSRTKTLL FISNDKKVVG
   721  CLIAEHIQWG YRVIEEKLPV IRSEEEKVRF ERQKAWCCST LPEPAICGIS RIWVFSMMRR
   781  KKIASRMIEC LRSNFIYGSY LSKEEIAFSD PTPDGKLFAT QYCGTGQFLV YNFINGQNST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESCO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
bone marrow: 15 nTPM
thymus: 10 nTPM
breast: 9.8 nTPM
skeletal muscle: 9.8 nTPM
epididymis: 9.5 nTPM

Single-cell type

myonuclei: 233 nCPM
neutrophils: 226 nCPM
early primary spermatocytes: 150 nCPM
sertoli cells: 149 nCPM
somatotrophs: 126 nCPM
differentiating spermatogonia: 117 nCPM

Immune cell

basophil: 4.9 nTPM
eosinophil: 3.9 nTPM
gdT-cell: 3.3 nTPM
naive CD8 T-cell: 3.3 nTPM
neutrophil: 3.2 nTPM
memory CD8 T-cell: 3.1 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 11 nTPM
white matter: 10 nTPM
pons: 9.3 nTPM
cerebral cortex: 8.9 nTPM
basal ganglia: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ESCO1 as an antibody target. Whether an autoantibody or antibody against ESCO1 could matter depends on whether native ESCO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ESCO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ESCO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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