Seroatlas · Human Serome Atlas

ERVV-2

Endogenous retrovirus group V member 2 Env polyprotein

Also known as: ENVV2, ERVV2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B6SEH9
Gene: ERVV-2
Ensembl: ENSG00000268964
Chromosome: 19
Canonical length: 535 aa
Protein class: Predicted membrane proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>B6SEH9|ERVV-2
     1  MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
    61  LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
   121  LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
   181  NRCAAWEGKE LITWRVLYSL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
   241  DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
   301  LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
   361  KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA VINKSCCVYV NNSGAIEEDI
   421  KKIYDEATWL HDFGKGGASA RAIWEAVKSA LPSLNWFVPL LGPATVILLL FLFGPCFFNL
   481  LIKCVSSRIK QFHMKSPQME RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVV-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

placenta: 7.9 nTPM
skeletal muscle: 0.5 nTPM
bone marrow: 0.2 nTPM
kidney: 0.2 nTPM
skin: 0.1 nTPM
testis: 0.1 nTPM

Single-cell type

syncytiotrophoblasts: 133 nCPM
cytotrophoblasts: 4.7 nCPM
migrating cytotrophoblasts: 3.3 nCPM
foveolar cells: 1.5 nCPM
gastric progenitor cells: 1.3 nCPM
thymocytes: 0.8 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2.1 nTPM
white matter: 1.8 nTPM
cerebral cortex: 1.6 nTPM
pons: 1.5 nTPM
amygdala: 1.4 nTPM
basal ganglia: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.67

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVV-2 as an antibody target. Whether an autoantibody or antibody against ERVV-2 could matter depends on whether native ERVV-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVV-2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVV-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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