Seroatlas · Human Serome Atlas

ERVV-1

Endogenous retrovirus group V member 1 Env polyprotein

Also known as: ENVV1, ERVV1_HUMAN, FLJ32214, HERV-V1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B6SEH8
Gene: ERVV-1
Ensembl: ENSG00000269526
Chromosome: 19
Canonical length: 477 aa
Protein class: Predicted membrane proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. The gene's envelope protein is expressed in the human placenta but is truncated at its C-terminus. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>B6SEH8|ERVV-1
     1  MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
    61  LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
   121  LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
   181  NRCAAWEGKE LITWRVLYLL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
   241  DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
   301  LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
   361  KSTRDSISKL KASIDSLANV VMNNRLALDY LLAEQGGVCA VISKSCCIYV NNSGAIEEDI
   421  KKIYDEVTWL HNFGKGDSAG SIWEAVKSAL PSLTWFVPLL GPAALNSLLS PLWPLSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVV-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

placenta: 15 nTPM
cerebellum: 1 nTPM
kidney: 0.8 nTPM
vagina: 0.4 nTPM
cervix: 0.2 nTPM
prostate: 0.2 nTPM

Single-cell type

syncytiotrophoblasts: 386 nCPM
cytotrophoblasts: 8.4 nCPM
migrating cytotrophoblasts: 6.2 nCPM
breast lactating cells: 1.5 nCPM
extravillous trophoblasts: 1.3 nCPM
retinal amacrine cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
basal ganglia: 0.8 nTPM
cerebral cortex: 0.8 nTPM
hippocampal formation: 0.6 nTPM
pons: 0.6 nTPM
hypothalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.24

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVV-1 as an antibody target. Whether an autoantibody or antibody against ERVV-1 could matter depends on whether native ERVV-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVV-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVV-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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