Seroatlas · Human Serome Atlas

ERVS71-1

Endogenous retrovirus group S71 member 1 Env polyprotein

Also known as: ENVT1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61550
Gene: ERVS71-1
Canonical length: 626 aa

OverviewNCBI Gene

No narrative summary is available for ERVS71-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>P61550|ERVS71-1
     1  MGPEAWVRPL KTAPKPGEAI RLILFIYLSC FFLPVMSSEP SYSFLLTSFT TGRVFANTTW
    61  RAGTSKEVSF AVDLCVLFPE PARTHEEQHN LPVIGAGSVD LAAGFGHSGS QTGCGSSKGA
   121  EKGLQNVDFY LCPGNHPDAS CRDTYQFFCP DWTCVTLATY SGGSTRSSTL SISRVPHPKL
   181  CTRKNCNPLT ITVHDPNAAQ WYYGMSWGLR LYIPGFDVGT MFTIQKKILV SWSSPKPIGP
   241  LTDLGDPIFQ KHPDKVDLTV PLPFLVPRPQ LQQQHLQPSL MSILGGVHHL LNLTQPKLAQ
   301  DCWLCLKAKP PYYVGLGVEA TLKRGPLSCH TRPRALTIGD VSGNASCLIS TGYNLSASPF
   361  QATCNQSLLT SISTSVSYQA PNNTWLACTS GLTRCINGTE PGPLLCVLVH VLPQVYVYSG
   421  PEGRQLIAPP ELHPRLHQAV PLLVPLLAGL SIAGSAAIGT AALVQGETGL ISLSQQVDAD
   481  FSNLQSAIDI LHSQVESLAE VVLQNCRCLD LLFLSQGGLC AALGESCCFY ANQSGVIKGT
   541  VKKVRENLDR HQQERENNIP WYQSMFNWNP WLTTLITGLA GPLLILLLSL IFGPCILNSF
   601  LNFIKQRIAS VKLTYLKTQY DTLVNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVS71-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVS71-1 as an antibody target. Whether an autoantibody or antibody against ERVS71-1 could matter depends on whether native ERVS71-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVS71-1 is annotated at the cell surface, where native ERVS71-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVS71-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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