Seroatlas · Human Serome Atlas

ERVPABLB-1

Endogenous retrovirus group PABLB member 1 Env polyprotein

Also known as: ERB1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60509
Gene: ERVPABLB-1
Canonical length: 514 aa

OverviewNCBI Gene

No narrative summary is available for ERVPABLB-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>P60509|ERVPABLB-1
     1  MDPLHTIEKV PARRNIHDRG HQGHRMGDGT PGRPKISVQQ MTRFSLIIFF LSAPFVVNAS
    61  TSNVFLQWAH SYADGLQQGD PCWVCGSLPV TNTMELPWWV SPLQGKDWVF FQSFIGDLKQ
   121  WTGAQMTGVT RKNISEWPIN KTLNEPGHDK PFSVNETRDK VIAFAIPLLD TKVFVQTSRP
   181  QNTQYRNGFL QIWDGFIWLT ATKGHLSQIA PLCWEQRNHS LDNWPNTTRV MGWIPPGQCR
   241  HTILLQQRDL FATDWSQQPG LNWYAPNGTQ WLCSPNLWPW LPSGWLGCCT LGIPWAQGRW
   301  VKTMEVYPYL PHVVNQGTRA IVHRNDHLPT IFMPSVGLGT VIQHIEALAN FTQRALNDSL
   361  QSISLMNAEV YYMHEDILQN RMALDILTAA EGGTCALIKT ECCVYIPNNS RNISLALEDT
   421  CRQIQVISSS ALSLHDWIAS QFSGRPSWWQ KILIVLATLW SVGIALCCGL YFCRMFSQHI
   481  PQTHSIIFQQ ELPLSPPSQE HYQSQRDIFH SNAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVPABLB-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVPABLB-1 as an antibody target. Whether an autoantibody or antibody against ERVPABLB-1 could matter depends on whether native ERVPABLB-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVPABLB-1 is annotated at the cell surface, where native ERVPABLB-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVPABLB-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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