Seroatlas · Human Serome Atlas

ERVMER34-1

Endogenous retroviral envelope protein HEMO

Also known as: envMER34, MER34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9K5
Gene: ERVMER34-1
Ensembl: ENSG00000226887
Chromosome: 4
Canonical length: 563 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q9H9K5|ERVMER34-1
     1  MGSLSNYALL QLTLTAFLTI LVQPQHLLAP VFRTLSILTN QSNCWLCEHL DNAEQPELVF
    61  VPASASTWWT YSGQWMYERV WYPQAEVQNH STSSYRKVTW HWEASMEAQG LSFAQVRLLE
   121  GNFSLCVENK NGSGPFLGNI PKQYCNQILW FDSTDGTFMP SIDVTNESRN DDDDTSVCLG
   181  TRQCSWFAGC TNRTWNSSAV PLIGLPNTQD YKWVDRNSGL TWSGNDTCLY SCQNQTKGLL
   241  YQLFRNLFCS YGLTEAHGKW RCADASITND KGHDGHRTPT WWLTGSNLTL SVNNSGLFFL
   301  CGNGVYKGFP PKWSGRCGLG YLVPSLTRYL TLNASQITNL RSFIHKVTPH RCTQGDTDNP
   361  PLYCNPKDNS TIRALFPSLG TYDLEKAILN ISKAMEQEFS ATKQTLEAHQ SKVSSLASAS
   421  RKDHVLDIPT TQRQTACGTV GKQCCLYINY SEEIKSNIQR LHEASENLKN VPLLDWQGIF
   481  AKVGDWFRSW GYVLLIVLFC LFIFVLIYVR VFRKSRRSLN SQPLNLALSP QQSAQLLVSE
   541  TSCQVSNRAM KGLTTHQYDT SLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVMER34-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 12 nTPM
placenta: 10 nTPM
kidney: 3.2 nTPM
heart muscle: 2.4 nTPM
ovary: 1.3 nTPM
esophagus: 1.1 nTPM

Single-cell type

migrating cytotrophoblasts: 143 nCPM
extravillous trophoblasts: 115 nCPM
cytotrophoblasts: 101 nCPM
syncytiotrophoblasts: 17 nCPM
podocytes: 12 nCPM
esophageal basal cells: 11 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.1 nTPM
pons: 1.7 nTPM
amygdala: 1.6 nTPM
spinal cord: 1.5 nTPM
white matter: 1.5 nTPM
medulla oblongata: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 2.01

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

TLV/ENV coat polyprotein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVMER34-1 as an antibody target. Whether an autoantibody or antibody against ERVMER34-1 could matter depends on whether native ERVMER34-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVMER34-1 is annotated at the cell surface, where native ERVMER34-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVMER34-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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