Seroatlas · Human Serome Atlas

ERVK13-1

Endogenous retrovirus group K member 13-1 Env polyprotein

Also known as: ENK13_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX77
Gene: ERVK13-1
Canonical length: 482 aa

OverviewNCBI Gene

No narrative summary is available for ERVK13-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9NX77|ERVK13-1
     1  MWTVPSFTND SYQVYNVFST NSFQLLTVKR TPHEAWRVPL TTKTNKTKGL PDCPKKPTNG
    61  PFIVTSILWD NCNAPKAVVL QTLAMGIVID WAPKGHYWQD CSSKNTLCSE FIYSLDYIEH
   121  GWQSYTMRQR VSPYPFKWMD TGIAPPRPKI IHPFFTPEHP ELWKLAAALS GIKIWNTTYQ
   181  LLRTKTKTPT FNITLISEWV IPIRSCVKPP YMLLVGNIIM MPDAQTIECH NCKLFTCIDA
   241  TFNPTTSILL VRAREGVWIP VSLHRPWESS PSIHIVNEVL KDILKRTKRF IFTLIAVLAG
   301  LLAVTATAAT AGVAIRSSVQ TAHYVEACQK NSSRLWNSQA QIDQKLANQI NDLRQSVTWL
   361  GDRVMNLQHR MQLQCDWNTS DYCITPYAYN QDQHSWENVS RHLKAWDDNL TLDISQLKEQ
   421  IFEASQAHLS TVPGSHIFEG ITKQLPDFNP FKWLKPVRGS LLLLALLILV CLCCLLLVCR
   481  CL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK13-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41

OntologyGO

Molecular functions

structural molecule activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK13-1 as an antibody target. Whether an autoantibody or antibody against ERVK13-1 could matter depends on whether native ERVK13-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK13-1 is annotated at the cell surface, where native ERVK13-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVK13-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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