Seroatlas · Human Serome Atlas

ERVK11-1

Putative endogenous retrovirus group K member 11-1 Env polyprotein

Also known as: ENK11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61568
Gene: ERVK11-1
Canonical length: 191 aa

OverviewNCBI Gene

No narrative summary is available for ERVK11-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>P61568|ERVK11-1
     1  MPGAIDDHCP AQPGEEGTAF NVTMGYKYPP LCLGHATRCI HLETQVWAAY LLERLATGKW
    61  GHLVSGLSLC PLRQMKRGVI GDTPYFQYKP VGKLCPKNFE GPSKTLIWGD CVNSHAVVLK
   121  NDSYALVIDW APKGYLKNTC SSGGGEFLEA TYFISYWEDE DHHPTLHRWF GSFFTLKWED
   181  KDITLHPQGL V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK11-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK11-1 as an antibody target. Whether an autoantibody or antibody against ERVK11-1 could matter depends on whether native ERVK11-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK11-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVK11-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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