ERVK-5
Endogenous retrovirus group K member 5 Gag polyprotein
Also known as: GAK5_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-5 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
667 residues, UniProt reviewed canonical sequence.
>Q9HDB9|ERVK-5
1 MGQTKSKTKS KYASYLSFIK ILLKRGGVRV STKNLIKLFQ IIEQFCPWFP EQGTLDLKDW
61 KRIGEELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTKED SVSVSDAPGS CVIDCNEKTG
121 RKSQKETESL HCEYVTEPVM AQSTQNVDYN QLQGVIYPET LKLEGKGPEL VGPSESKPRG
181 PSPLPAGQVP VTLQPQTQVK ENKTQPPVAY QYWPPAELQY LPPPESQYGY PGMPPALQGR
241 APYPQPPTVR LNPTASRSGQ GGTLHAVIDE ARKQGDLEAW RFLVILQLVQ AGEETQVGAP
301 ARAETRCEPF TMKMLKDIKE GVKQYGSNSP YIRTLLDSIA HGNRLTPYDW ESLAKSSLSS
361 SQYLQFKTWW IDGVQEQVRK NQATKPTVNI DADQLLGTGP NWSTINQQSV MQNEAIEQVR
421 AICLRAWGKI QDPGTAFPIN SIRQGSKEPY PDFVARLQDA AQKSITDDNA RKVIVELMAY
481 ENANPECQSA IKPLKGKVPA GVDVITEYVK ACDGIGGAMH KAMLMAQAMR GLTLGGQVRT
541 FGKKCYNCGQ IGHLKRSCPV LNKQNIINQA ITAKNKKPSG LCPKCGKGKH WANQCHSKFD
601 KDGQPLSGNR KRGQPQAPQQ TGAFPVQLFV PQGFQGQQPL QKIPPLQGVS QLQQSNSCPA
661 PQQAAPQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, CCHC-type
- Beta-retroviral matrix protein
- Retrovirus capsid, C-terminal
- Retrovirus capsid, N-terminal
- Retroviral matrix protein
- Zinc finger, CCHC-type superfamily
- Beta-retroviral matrix superfamily
- Retroviral nucleocapsid Gag protein p24, C-terminal domain
- Primate lentivirus group Gag polyprotein-like
- Zinc knuckle
- gag protein p24 N-terminal domain
- Retroviral GAG p10 protein
- GAG-polyprotein viral zinc-finger
- Gag protein p24 C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-5 as an antibody target. Whether an autoantibody or antibody against ERVK-5 could matter depends on whether native ERVK-5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-5 is annotated at the cell surface, where native ERVK-5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ERVK-5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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