Seroatlas · Human Serome Atlas

ERVK-24

Endogenous retrovirus group K member 24 Gag polyprotein

Also known as: GAK24_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63145
Gene: ERVK-24
Canonical length: 666 aa

OverviewNCBI Gene

No narrative summary is available for ERVK-24 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>P63145|ERVK-24
     1  MGQTKSKIKS KYASYLSFIK ILLKRGGVKV STKNLIKLFQ IIEQFCPWFP EQGTLDLKDW
    61  KRIGKELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTEED SVSVSDAPGS CLIDCNEKTR
   121  KKSQKETESL HCEYVAEPVM AQSTQNVDYN QLQEVIYPET LKLEGKGPEL VGPSESKPRG
   181  TSPLPAGQVP VTLQPQKQVK ENKTQPPVAY QYWPPAELQY RPPPESQYGY PGMPPAPQGR
   241  APYPQPPTRR LNPTAPPSRQ GSELHEIIDK SRKEGDTEAW QFPVTLEPMP PGEGAQEGEP
   301  PTVEARYKSF SIKMLKDMKE GVKQYGPNSP YMRTLLDSIA YGHRLIPYDW EILAKSSLSP
   361  SQFLQFKTWW IDGVQEQVRR NRAANPPVNI DADQLLGIGQ NWSTISQQAL MQNEAIEQVR
   421  AICLRAWEKI QDPGSACPSF NTVRQGSKEP YPDFVARLQD VAQKSIADEK ARKVIVELMA
   481  YENANPECQS AIKPLKGKVP AGSDVISEYV KACDGIGGAM HKAMLMAQAI TGVVLGGQVR
   541  TFGGKCYNCG QIGHLKKNCP VLNKQNITIQ ATTTGREPPD LCPRCKKGKH WASQCRSKFD
   601  KNGQPLSGNE QRGQPQAPQQ TGAFPIQPFV PQGFQGQQPP LSQVFQGISQ LPQYNNCPLP
   661  QAAVQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK-24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERVK-24.

Disease | ImmuneIEDB

Conditions an epitope on ERVK-24 was assayed in.

prostate cancer B cell

OntologyGO

Biological processes

viral translational frameshifting

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK-24 as an antibody target. Whether an autoantibody or antibody against ERVK-24 could matter depends on whether native ERVK-24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK-24 is annotated at the cell surface, where native ERVK-24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVK-24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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