Seroatlas · Human Serome Atlas

ERVH48-1

Suppressyn

Also known as: C21orf105, NDUFV3-AS1, SUPYN, SUPYN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
M5A8F1
Gene
ERVH48-1
Ensembl
ENSG00000233056
Chromosome
21
Canonical length
160 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in female reproductive system

OverviewNCBI Gene

Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>M5A8F1|ERVH48-1
     1  MACIYPTTFY TSLPTKSLNM GISLTTILIL SVAVLLSTAA PPSCRECYQS LHYRGEMQQY
    61  FTYHTHIERS CYGNLIEECV ESGKSYYKVK NLGVCGSRNG AICPRGKQWL CFTKIGQWGV
   121  NTQVLEDIKR EQIIAKAKAS KPTTPPENRP RHFHSFIQKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVH48-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 144 nTPM
  • retina: 1.4 nTPM
  • testis: 1.3 nTPM
  • thymus: 1.2 nTPM
  • skin: 0.8 nTPM
  • pancreas: 0.7 nTPM

Single-cell type

  • extravillous trophoblasts: 371 nCPM
  • migrating cytotrophoblasts: 207 nCPM
  • cytotrophoblasts: 165 nCPM
  • syncytiotrophoblasts: 96 nCPM
  • epicardial cells: 30 nCPM
  • cardiomyocytes: 25 nCPM

Immune cell

  • neutrophil: 7.8 nTPM
  • eosinophil: 1.3 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • basophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebellum: 16 nTPM
  • cerebral cortex: 14 nTPM
  • pons: 13 nTPM
  • medulla oblongata: 12 nTPM
  • basal ganglia: 12 nTPM
  • thalamus: 12 nTPM

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVH48-1 as an antibody target. Whether an autoantibody or antibody against ERVH48-1 could matter depends on whether native ERVH48-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVH48-1 is annotated as secreted, so native ERVH48-1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ERVH48-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERVH48-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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