Seroatlas · Human Serome Atlas

ERVFC1-1

Endogenous retrovirus group FC1 member 1 Env polyprotein

Also known as: EFC2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60608
Gene: ERVFC1-1
Canonical length: 527 aa

OverviewNCBI Gene

No narrative summary is available for ERVFC1-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>P60608|ERVFC1-1
     1  MNSPCDRLQQ FIQVLLEESW SFPSFANTLH WPENLLSYID ELVWQGSLQN FHQHEVRFDK
    61  PPLRLPLTGF SSLTENWSSR QAVSSRLVAT AASPPAGCQA PIAFLGLKFS SLGPARKNPA
   121  LCFLYDQSNS KCNTSWVKEN VGCPWHWCNI HEALIRTEKG SDPMFYVNTS TGGRDGFNGF
   181  NLQISDPWDP RWASGVDGGL YEHKTFMYPV AKIRIARTLK TTVTGLSDLA SSIQSAEKEL
   241  TSQLQPAADQ AKSSRFSWLT LISEGAQLLQ STGVQNLSHC FLCAALRRPP LVAVPLPTPF
   301  NYTINSSTPI PPVPKGQVPL FSDPIRHKFP FCYSTPNASW CNQTRMLTST PAPPRGYFWC
   361  NSTLTKVLNS TGNHTLCLPI SLIPGLTLYS QDELSHLLAW TEPRPQNKSK WAIFLPLVLG
   421  ISLASSLVAS GLGKGALTHS IQTSQDLSTH LQLAIEASAE SLDSLQRQIT TVAQVAAQNR
   481  QALDLLMAEK GRTCLFLQEE CCYYLNESGV VENSLQTLKK KKSSKRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVFC1-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41

OntologyGO

Biological processes

viral translational frameshifting

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVFC1-1 as an antibody target. Whether an autoantibody or antibody against ERVFC1-1 could matter depends on whether native ERVFC1-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVFC1-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVFC1-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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