Seroatlas · Human Serome Atlas

ERVFC1

Endogenous retrovirus group FC1 Env polyprotein

Also known as: EFC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60507
Gene: ERVFC1
Canonical length: 584 aa

OverviewNCBI Gene

No narrative summary is available for ERVFC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>P60507|ERVFC1
     1  MARPSPLCLL LLLTLLTPIV PSNSLLTEPP FRWRFYLHET WTQGNRLSTV TLATVDCQPH
    61  GCQAQVTFNF TSFKSVLRGW SNPTICFVYD QTHSNCRDYW VDTNGGCPYA YCRMHVTQLH
   121  TAKKLQHTYR LTSDGRTTYF LTIPDPWDSR WVSGVTGRLY RWPTDSYPVG KLRIFLTYIR
   181  VIPQVLSNLK DQADNIKHQE EVINTLVQSH PKADMVTYDD KAEAGPFSWI TLVRHGARLV
   241  NMAGLVNLSH CFLCTALSQP PLVAVPLPQA FNTSGNHTAH PSGVFSEQVP LFRDPLQPQF
   301  PFCYTTPNSS WCNQTYSGSL SNLSAPAGGY FWCNFTLTKH LNISSNNTLS RNLCLPISLV
   361  PRLTLYSEAE LSSLVNPPMR QKRAVFPPLV IGVSLTSSLV ASGLGTGAIV HFISSSQDLS
   421  IKLQMAIEAS AESLASLQRQ ITSVAKVAMQ NRRALDLLTA DKGGTCMFLG EECCYYINES
   481  GLVETSLLTL DKIRDGLHRP SSTPNYGGGW WQSPLTTWII PFISPILIIC LLLLIAPCVL
   541  KFIKNRISEV SRVTVNQMLL HPYSRLPTSE DHYDDALTQQ EAAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVFC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVFC1 as an antibody target. Whether an autoantibody or antibody against ERVFC1 could matter depends on whether native ERVFC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVFC1 is annotated at the cell surface, where native ERVFC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVFC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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