Seroatlas · Human Serome Atlas

ERV3-1

Endogenous retrovirus group 3 member 1 Env polyprotein

Also known as: ENR1_HUMAN, envR, ERV-R, ERV3, H-PLK, HERV-R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14264
Gene: ERV3-1
Ensembl: ENSG00000213462
Chromosome: 7
Canonical length: 604 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>Q14264|ERV3-1
     1  MLGMNMLLIT LFLLLPLSML KGEPWEGCLH CTHTTWSGNI MTKTLLYHTY YECAGTCLGT
    61  CTHNQTTYSV CDPGRGQPYV CYDPKSSPGT WFEIHVGSKE GDLLNQTKVF PSGKDVVSLY
   121  FDVCQIVSMG SLFPVIFSSM EYYSSCHKNR YAHPACSTDS PVTTCWDCTT WSTNQQSLGP
   181  IMLTKIPLEP DCKTSTCNSV NLTILEPDQP IWTTGLKAPL GARVSGEEIG PGAYVYLYII
   241  KKTRTRSTQQ FRVFESFYEH VNQKLPEPPP LASNLFAQLA ENIASSLHVA SCYVCGGMNM
   301  GDQWPWEARE LMPQDNFTLT ASSLEPAPSS QSIWFLKTSI IGKFCIARWG KAFTDPVGEL
   361  TCLGQQYYNE TLGKTLWRGK SNNSESPHPS PFSRFPSLNH SWYQLEAPNT WQAPSGLYWI
   421  CGPQAYRQLP AKWSGACVLG TIRPSFFLMP LKQGEALGYP IYDETKRKSK RGITIGDWKD
   481  NEWPPERIIQ YYGPATWAED GMWGYRTPVY MLNRIIRLQA VLEIITNETA GALNLLAQQA
   541  TKMRNVIYQN RLALDYLLAQ EEGVCGKFNL TNCCLELDDE GKVIKEITAK IQKLAHIPVQ
   601  TWKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERV3-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 32 nTPM
epididymis: 31 nTPM
adipose tissue: 21 nTPM
gallbladder: 15 nTPM
esophagus: 15 nTPM
parathyroid gland: 14 nTPM

Single-cell type

platelets: 110 nCPM
late primary spermatocytes: 14 nCPM
sertoli cells: 14 nCPM
epididymal principal cells: 5.3 nCPM
neutrophils: 5 nCPM
esophageal apical cells: 4.6 nCPM

Immune cell

neutrophil: 7 nTPM
eosinophil: 2.4 nTPM
intermediate monocyte: 1.8 nTPM
T-reg: 1.2 nTPM
NK-cell: 1.1 nTPM
classical monocyte: 1 nTPM

Brain region

midbrain: 22 nTPM
medulla oblongata: 19 nTPM
hypothalamus: 19 nTPM
cerebral cortex: 17 nTPM
pons: 17 nTPM
choroid plexus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.73
DepMap mean gene effect: -0.03
DepMap dependency class: none

Protein domainsUniProt · Pfam · InterPro

TLV/ENV coat polyprotein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERV3-1 as an antibody target. Whether an autoantibody or antibody against ERV3-1 could matter depends on whether native ERV3-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERV3-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERV3-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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