Seroatlas · Human Serome Atlas

ERO1B

ERO1-like protein beta

Also known as: ERO1-L(beta), ERO1B_HUMAN, Ero1beta, ERO1LB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YB8
Gene
ERO1B
Ensembl
ENSG00000086619
Chromosome
1
Canonical length
467 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein-disulfide reductase activity and thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q86YB8|ERO1B
     1  MSQGVRRAGA GQGVAAAVQL LVTLSFLRSV VEAQVTGVLD DCLCDIDSID NFNTYKIFPK
    61  IKKLQERDYF RYYKVNLKRP CPFWAEDGHC SIKDCHVEPC PESKIPVGIK AGHSNKYLKM
   121  ANNTKELEDC EQANKLGAIN STLSNQSKEA FIDWARYDDS RDHFCELDDE RSPAAQYVDL
   181  LLNPERYTGY KGTSAWRVWN SIYEENCFKP RSVYRPLNPL APSRGEDDGE SFYTWLEGLC
   241  LEKRVFYKLI SGLHASINLH LCANYLLEET WGKPSWGPNI KEFKHRFDPV ETKGEGPRRL
   301  KNLYFLYLIE LRALSKVAPY FERSIVDLYT GNAEEDADTK TLLLNIFQDT KSFPMHFDEK
   361  SMFAGDKKGA KSLKEEFRLH FKNISRIMDC VGCDKCRLWG KLQTQGLGTA LKILFSEKEI
   421  QKLPENSPSK GFQLTRQEIV ALLNAFGRLS TSIRDLQNFK VLLQHSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERO1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
173 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 173 nTPM
  • stomach: 40 nTPM
  • testis: 31 nTPM
  • thyroid gland: 29 nTPM
  • liver: 20 nTPM
  • epididymis: 18 nTPM

Single-cell type

  • pancreatic islet cells: 743 nCPM
  • pancreatic acinar cells: 431 nCPM
  • gastric chief cells: 323 nCPM
  • pancreatic duct cells: 259 nCPM
  • neuroendocrine cells: 247 nCPM
  • epididymal principal cells: 220 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • eosinophil: 2.2 nTPM
  • plasmacytoid DC: 2.2 nTPM
  • MAIT T-cell: 1.4 nTPM
  • neutrophil: 1.2 nTPM
  • myeloid DC: 1.1 nTPM

Brain region

  • choroid plexus: 8.9 nTPM
  • cerebellum: 6.4 nTPM
  • midbrain: 5.6 nTPM
  • white matter: 5.5 nTPM
  • cerebral cortex: 5.3 nTPM
  • spinal cord: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERO1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERO1B as an antibody target. Whether an autoantibody or antibody against ERO1B could matter depends on whether native ERO1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERO1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERO1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERO1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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