Seroatlas · Human Serome Atlas

ERN2

Serine/threonine-protein kinase/endoribonuclease IRE2

Also known as: ERN2_HUMAN, IRE1b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q76MJ5
Gene
ERN2
Ensembl
ENSG00000134398
Chromosome
16
Canonical length
926 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of DNA-templated transcription; and rRNA catabolic process. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

926 residues, UniProt reviewed canonical sequence.

>Q76MJ5|ERN2
     1  MASAVRGSRP WPRLGLQLQF AALLLGTLSP QVHTLRPENL LLVSTLDGSL HALSKQTGDL
    61  KWTLRDDPVI EGPMYVTEMA FLSDPADGSL YILGTQKQQG LMKLPFTIPE LVHASPCRSS
   121  DGVFYTGRKQ DAWFVVDPES GETQMTLTTE GPSTPRLYIG RTQYTVTMHD PRAPALRWNT
   181  TYRRYSAPPM DGSPGKYMSH LASCGMGLLL TVDPGSGTVL WTQDLGVPVM GVYTWHQDGL
   241  RQLPHLTLAR DTLHFLALRW GHIRLPASGP RDTATLFSTL DTQLLMTLYV GKDETGFYVS
   301  KALVHTGVAL VPRGLTLAPA DGPTTDEVTL QVSGEREGSP STAVRYPSGS VALPSQWLLI
   361  GHHELPPVLH TTMLRVHPTL GSGTAETRPP ENTQAPAFFL ELLSLSREKL WDSELHPEEK
   421  TPDSYLGLGP QDLLAASLTA VLLGGWILFV MRQQQPQVVE KQQETPLAPA DFAHISQDAQ
   481  SLHSGASRRS QKRLQSPSKQ AQPLDDPEAE QLTVVGKISF NPKDVLGRGA GGTFVFRGQF
   541  EGRAVAVKRL LRECFGLVRR EVQLLQESDR HPNVLRYFCT ERGPQFHYIA LELCRASLQE
   601  YVENPDLDRG GLEPEVVLQQ LMSGLAHLHS LHIVHRDLKP GNILITGPDS QGLGRVVLSD
   661  FGLCKKLPAG RCSFSLHSGI PGTEGWMAPE LLQLLPPDSP TSAVDIFSAG CVFYYVLSGG
   721  SHPFGDSLYR QANILTGAPC LAHLEEEVHD KVVARDLVGA MLSPLPQPRP SAPQVLAHPF
   781  FWSRAKQLQF FQDVSDWLEK ESEQEPLVRA LEAGGCAVVR DNWHEHISMP LQTDLRKFRS
   841  YKGTSVRDLL RAVRNKKHHY RELPVEVRQA LGQVPDGFVQ YFTNRFPRLL LHTHRAMRSC
   901  ASESLFLPYY PPDSEARRPC PGATGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 49 nTPM
  • colon: 28 nTPM
  • salivary gland: 23 nTPM
  • rectum: 22 nTPM
  • cervix: 18 nTPM
  • gallbladder: 16 nTPM

Single-cell type

  • goblet cells: 270 nCPM
  • respiratory secretory cells: 179 nCPM
  • foveolar cells: 165 nCPM
  • prostatic club cells: 153 nCPM
  • prostatic hillock cells: 118 nCPM
  • colonocytes: 109 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.3 nTPM
  • NK-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • cerebellum: 2.3 nTPM
  • cerebral cortex: 1.8 nTPM
  • white matter: 1.7 nTPM
  • basal ganglia: 1.4 nTPM
  • choroid plexus: 1.4 nTPM
  • hypothalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
-0.29
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERN2 as an antibody target. Whether an autoantibody or antibody against ERN2 could matter depends on whether native ERN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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