Seroatlas · Human Serome Atlas

ERMP1

Endoplasmic reticulum metallopeptidase 1

Also known as: ERMP1_HUMAN, FLJ23309, FXNA, KIAA1815

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2K6
Gene: ERMP1
Ensembl: ENSG00000099219
Chromosome: 9
Canonical length: 904 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity and metalloexopeptidase activity. Involved in cellular response to oxidative stress. Acts upstream of or within endoplasmic reticulum unfolded protein response. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q7Z2K6|ERMP1
     1  MEWGSESAAV RRHRVGVERR EGAAAAPPPE REARAQEPLV DGCSGGGRTR KRSPGGSGGA
    61  SRGAGTGLSE VRAALGLALY LIALRTLVQL SLQQLVLRGA AGHRGEFDAL QARDYLEHIT
   121  SIGPRTTGSP ENEILTVHYL LEQIKLIEVQ SNSLHKISVD VQRPTGSFSI DFLGGFTSYY
   181  DNITNVVVKL EPRDGAQHAV LANCHFDSVA NSPGASDDAV SCSVMLEVLR VLSTSSEALH
   241  HAVIFLFNGA EENVLQASHG FITQHPWASL IRAFINLEAA GVGGKELVFQ TGPENPWLVQ
   301  AYVSAAKHPF ASVVAQEVFQ SGIIPSDTDF RIYRDFGNIP GIDLAFIENG YIYHTKYDTA
   361  DRILTDSIQR AGDNILAVLK HLATSDMLAA ASKYRHGNMV FFDVLGLFVI AYPSRIGSII
   421  NYMVVMGVVL YLGKKFLQPK HKTGNYKKDF LCGLGITLIS WFTSLVTVLI IAVFISLIGQ
   481  SLSWYNHFYV SVCLYGTATV AKIILIHTLA KRFYYMNASA QYLGEVFFDI SLFVHCCFLV
   541  TLTYQGLCSA FISAVWVAFP LLTKLCVHKD FKQHGAQGKF IAFYLLGMFI PYLYALYLIW
   601  AVFEMFTPIL GRSGSEIPPD VVLASILAGC TMILSSYFIN FIYLAKSTKK TMLTLTLVCA
   661  ITFLLVCSGT FFPYSSNPAN PKPKRVFLQH MTRTFHDLEG NAVKRDSGIW INGFDYTGIS
   721  HITPHIPEIN DSIRAHCEEN APLCGFPWYL PVHFLIRKNW YLPAPEVSPR NPPHFRLISK
   781  EQTPWDSIKL TFEATGPSHM SFYVRAHKGS TLSQWSLGNG TPVTSKGGDY FVFYSHGLQA
   841  SAWQFWIEVQ VSEEHPEGMV TVAIAAHYLS GEDKRSPQLD ALKEKFPDWT FPSAWVCTYD
   901  LFVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 21 nTPM
kidney: 11 nTPM
salivary gland: 10 nTPM
esophagus: 8.7 nTPM
thyroid gland: 7.8 nTPM
urinary bladder: 7.6 nTPM

Single-cell type

epicardial cells: 487 nCPM
salivary duct cells: 204 nCPM
loop of henle epithelial cells: 194 nCPM
myonuclei: 183 nCPM
urothelial cells: 172 nCPM
adipocytes: 151 nCPM

Immune cell

NK-cell: 1.1 nTPM
MAIT T-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 22 nTPM
cerebellum: 20 nTPM
white matter: 19 nTPM
midbrain: 19 nTPM
basal ganglia: 16 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M28
Peptidase family M28
Peptidase M28 family
Endoplasmic reticulum metallopeptidase 1-like, M28 peptidase domain
Endoplasmic reticulum metallopeptidase 1-like, C-terminal domain
Endoplasmic reticulum metallopeptidase 1/1-A, TM domain
Endoplasmic reticulum metallopeptidase 1, C-terminal domain
Endoplasmic reticulum metallopeptidase 1, TM domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERMP1 as an antibody target. Whether an autoantibody or antibody against ERMP1 could matter depends on whether native ERMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...