Seroatlas · Human Serome Atlas

ERLN

Endoregulin

Also known as: C17orf110, ELN, ERLN_HUMAN, SMIM6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DI80
Gene: ERLN
Ensembl: ENSG00000259120
Chromosome: 17
Canonical length: 62 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to act upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

62 residues, UniProt reviewed canonical sequence.

>P0DI80|ERLN
     1  MDQLVFKETI WNDAFWQNPW DQGGLAVIIL FITAVLLLIL FAIVFGLLTS TENTQCEAGE
    61  EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

stomach: 31 nTPM
testis: 25 nTPM
fallopian tube: 23 nTPM
kidney: 22 nTPM
spinal cord: 12 nTPM
gallbladder: 9 nTPM

Single-cell type

late spermatids: 1,696 nCPM
early spermatids: 659 nCPM
epididymal clear cells: 182 nCPM
endometrial ciliated cells: 181 nCPM
fallopian tube ciliated cells: 154 nCPM
neuroendocrine cells: 125 nCPM

Immune cell

plasmacytoid DC: 34 nTPM
NK-cell: 0.8 nTPM
total PBMC: 0.3 nTPM
myeloid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 14 nTPM
pons: 10 nTPM
basal ganglia: 9.9 nTPM
medulla oblongata: 9.7 nTPM
midbrain: 9.6 nTPM
cerebellum: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP2A2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERLN as an antibody target. Whether an autoantibody or antibody against ERLN could matter depends on whether native ERLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...