Seroatlas · Human Serome Atlas

ERICH6B

Glutamate-rich protein 6B

Also known as: ERI6B_HUMAN, FAM194B, FLJ32682

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W0A0
Gene: ERICH6B
Ensembl: ENSG00000165837
Chromosome: 13
Canonical length: 696 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ERICH6B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q5W0A0|ERICH6B
     1  MSAENNQLSG ASPPHPPTTP QYSTQNLPSE KEDTEVELDE ESLQDESPFS PEGESLEDKE
    61  YLEEEEDLEE EEYLGKEEYL KEEEYLGKEE HLEEEEYLEK AGYLEEEEYI EEEEYLGKEG
   121  YLEEEEYLGK EEHLEEEEYL GKEGYLEKED YIEEVDYLGK KAYLEEEEYL GKKSYLEEEK
   181  ALEKEENLEE EEALEKEENL DGKENLYKKY LKEPKASYSS QTMLLRDARS PDAGPSQVTT
   241  FLTVPLTFAT PSPVSESATE SSELLLTLYR RSQASQTDWC YDRTAVKSLK SKSETEQETT
   301  TKLAPEEHVN TKVQQKKEEN VLEFASKENF WDGITDESID KLEVEDLDEN FLNSSYQTVF
   361  KTIIKEMAAH NELEEDFDIP LTKLLESENR WKLVIMLKKN YEKFKETILR IKRRREAQKL
   421  TEMTSFTFHL MSKPTPEKPE TEEIQKPQRV VHHRKKLERD KEWIQKKTVV HQGDGKLILY
   481  PNKNVYQILF PDGTGQIHYP SGNLAMLILY AKMKKFTYII LEDSLEGRIR ALINNSGNAT
   541  FYDENSDIWL NLSSNLGYYF PKDKRQKAWN WWNLNIHVHA PPVQPISLKI NEYIQVQIRS
   601  QDKIIFCFTY EQKQICLNLG TRYKFVIPEV LSEMKKKTIL EAEPGPTAQK IRVLLGKMNR
   661  LLNYATTPDL ENFIEAVSIS LMDNKYLKKM LSKLWF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

testis: 1.9 nTPM
choroid plexus: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 52 nCPM
early spermatids: 42 nCPM
cardiomyocytes: 37 nCPM
late spermatids: 28 nCPM
epicardial cells: 25 nCPM
ependymal cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.2 nTPM
basal ganglia: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH6B as an antibody target. Whether an autoantibody or antibody against ERICH6B could matter depends on whether native ERICH6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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