Seroatlas · Human Serome Atlas

ERICH6

Glutamate-rich protein 6

Also known as: C3orf44, ERICH6A, ERIP6_HUMAN, FAM194A, MGC39662

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L0X2
Gene: ERICH6
Ensembl: ENSG00000163645
Chromosome: 3
Canonical length: 663 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q7L0X2|ERICH6
     1  MAHLRSPSGF GDPGKKDQKE SEEELEEEEE EEEVEEEEEE VEEEEEEVEE EEEEVVEEEL
    61  VGEEQELEAP ETFSEEYLWK VTDIGDYDDD FPDVRPRLAS IVSPSLTSTF VPSQSATSTE
   121  TPSASPPSST SSHKSFPKIF QTFRKDMSEM SIDRNIHRNL SPGIPVSVQT EESWLQDLSD
   181  KVQSRKKASK EKAEPECLAS KLREKWVINP EESKLNILYE LEFKEDFITL FEPSLRTLPS
   241  IGPPSILAYK EESSNLGINF KDEEEETSPK CEFCGSDLRA FFSNVDVSSE PKGHASCCIA
   301  FQNLIDYIYE EQIKTKPPKA ELIAIDPHAA HGSEVDRLKA KEKALQRKQE QRMARHFAII
   361  SREQTHFSED DSKRLKTISY QLSVDIPEKQ IIDDIVFDFQ LRNSNMSIIC CDSRIACGKV
   421  VRNELLEKHY KHGSKFLTSF PDGTTQIFYP SGNLAIIRVP NKVNGFTCIV QEDMPTNPAI
   481  LAVLDSSGRS SCYHPNGNVW VYINILGGQY SDQAGNRIRA WNWSNSITSS PFVSFKPVFL
   541  ALNRYIGVRI LEQDKISITF LAMGQQARIS VGTKVKLPNP EEIPILRYVS GDDLLLLASL
   601  IKIRRLFHKL EGCVNFPSSQ VWEKLKQPSY LSSLSLKLIA LCHSSGIKQD IMKTIRNIIN
   661  EEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
epididymis: 1.6 nTPM
thyroid gland: 1.3 nTPM
duodenum: 0.6 nTPM
kidney: 0.6 nTPM
lymph node: 0.6 nTPM

Single-cell type

late primary spermatocytes: 142 nCPM
early spermatids: 132 nCPM
late spermatids: 129 nCPM
ependymal cells: 21 nCPM
sertoli cells: 20 nCPM
early primary spermatocytes: 17 nCPM

Immune cell

MAIT T-cell: 5.2 nTPM
NK-cell: 4.3 nTPM
gdT-cell: 2.7 nTPM
plasmacytoid DC: 2.4 nTPM
naive CD8 T-cell: 2.3 nTPM
naive CD4 T-cell: 2.2 nTPM

Brain region

choroid plexus: 3.6 nTPM
hypothalamus: 2.8 nTPM
basal ganglia: 2.6 nTPM
hippocampal formation: 2.6 nTPM
midbrain: 2.6 nTPM
cerebral cortex: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH6 as an antibody target. Whether an autoantibody or antibody against ERICH6 could matter depends on whether native ERICH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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