Seroatlas · Human Serome Atlas

ERICH5

Glutamate-rich protein 5

Also known as: C8orf47, ERIC5_HUMAN, FLJ39553

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P6B1
Gene: ERICH5
Ensembl: ENSG00000177459
Chromosome: 8
Canonical length: 374 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

No narrative summary is available for ERICH5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q6P6B1|ERICH5
     1  MGCSSSALNK AGDSSRFPSV TSNEHFSTAE ESESCFAQPK PHALGRESTV DGNVQRESRP
    61  PLQKLKVSAE PTANGVKPLQ EQPLAKDVAP GRDATDQSGS TEKTQPGEGL EESGPPQPGG
   121  KEDAPAAEGK KKDAGAGTEA ESLKGNAEAQ PLGPEAKGQP LQAAVEKDSL RAVEVTENPQ
   181  TAAEMKPLGT TENVLTLQIA GELQPQGTVG KDEQAPLLET ISKENESPEI LEGSQFVETA
   241  EEQQLQATLG KEEQPQLLER IPKENVTPEV LDRSQLVEKP VMNDPFHKTP EGPGNMEQIQ
   301  PEGIVGSMEH PARNVEAGAY VEMIRNIHTN EEDQRIEGET GEKVETDMEN EKVSEGAETK
   361  EEETGEVVDL SAAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

pancreas: 32 nTPM
stomach: 12 nTPM
gallbladder: 12 nTPM
fallopian tube: 10 nTPM
liver: 9.8 nTPM
heart muscle: 5.4 nTPM

Single-cell type

ocular epithelial cells: 350 nCPM
cholangiocytes: 109 nCPM
pancreatic duct cells: 93 nCPM
respiratory ciliated cells: 92 nCPM
fallopian tube ciliated cells: 65 nCPM
endometrial ciliated cells: 29 nCPM

Immune cell

myeloid DC: 2.2 nTPM
memory CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 9.3 nTPM
basal ganglia: 4.6 nTPM
midbrain: 4 nTPM
pons: 3.6 nTPM
medulla oblongata: 3.1 nTPM
cerebral cortex: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Glutamate-rich protein 5

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH5 as an antibody target. Whether an autoantibody or antibody against ERICH5 could matter depends on whether native ERICH5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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