Seroatlas · Human Serome Atlas

ERICH4

Glutamate-rich protein 4

Also known as: C19orf69, ERIC4_HUMAN, LOC100170765

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGS2
Gene
ERICH4
Ensembl
ENSG00000204978
Chromosome
19
Canonical length
130 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for ERICH4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>A6NGS2|ERICH4
     1  MELWRQLNQA GLVPPGLGPP PQALREVSPV EIPGQTLRTA GADTGGACDS LLWIREELGN
    61  LRRVDVQLLG QLCSLGLEMG ALREELVTIL EEEEESSKEE EEDQEPQRKQ EEEHLEACPA
   121  PHPPDFEMMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 40 nTPM
  • small intestine: 37 nTPM
  • kidney: 15 nTPM
  • heart muscle: 2 nTPM
  • skeletal muscle: 1.6 nTPM
  • lung: 1 nTPM

Single-cell type

  • enterocytes: 190 nCPM
  • epididymal efferent duct absorptive cells: 13 nCPM
  • paneth cells: 7.7 nCPM
  • enteric transient amplifying cells: 5 nCPM
  • early spermatids: 3.7 nCPM
  • proximal tubule cells: 3.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 1.8 nTPM
  • cerebral cortex: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM
  • thalamus: 1.6 nTPM
  • pons: 1.5 nTPM
  • basal ganglia: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0.04
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4530
  • Domain of unknown function (DUF4530)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH4 as an antibody target. Whether an autoantibody or antibody against ERICH4 could matter depends on whether native ERICH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERICH4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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