Seroatlas · Human Serome Atlas

ERICH3

Glutamate-rich protein 3

Also known as: C1orf173, DKFZp547I048, ERIC3_HUMAN, RP11-653A5.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5RHP9
Gene: ERICH3
Ensembl: ENSG00000178965
Chromosome: 1
Canonical length: 1530 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in cilium assembly. Located in cytoplasm and non-motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1530 residues, UniProt reviewed canonical sequence.

>Q5RHP9|ERICH3
     1  MSHSHPAGLL AAYNSLMDKH LAGYFNNTRI RRHLLRSGLI TRSGRILSEK EYKLNMMKRD
    61  HQKYIRECLA QAIFHKVLDM ERYHQLEIKK KLETLARKER IQRFKGEHTR RSVENNMPIL
   121  SPHPPVGPKS NRGHSVLVDE GHSSPLALTA PRPYTAPGNM QPPIRLQPLP SNPAVETVPK
   181  VTSRSRSKTS LLENEALFPI GGKKAVMKFR NSIGNSQRMN SYQLPNINSY MMPIPPPLPP
   241  TGKITRENRS ETWRRRRFRP TTAPNGLEPL LTKDSRRIHK TSLHSNAAIT MIYLGKNVHL
   301  SSDNPDFRDE IKVYQQHCGG ENLCVYKGKL LEKETFQFIS KRHHGFPFSL TFFLNGMQVN
   361  RLSSCCEYKH RKGSRLGGKR GYFGFVCVER SSPCYKCIIA MGLDKKPSLP KSRKEKSTEK
   421  GEELKKAEGK VRKEREYVIP KRNEIKENKT SVSAKFSAQE IKTGLKEVVT AVEEMTSKGK
   481  PGQEVLEDDQ ENTLKYEYEE DFEVDEEKQG EKSNEEGQAD VQMNGIPQSP LDDKKDNLDP
   541  EKESETSSQK APDARDNVKD ENDGCSESEL EEDKQDMKTA SSTSSRSHPY SSDSEDESAV
   601  GDREAHTDSS TDESARRSSS QELSENDKPR KSHLPIEESL EIEIEDQEIT KADVETKPMP
   661  IDESFENVLK EGTEKGTQEI AEGLSEKSGK HVSAEEKEKD KSKLWEESTA QVKDKKAGLP
   721  GLEEGGKDSL PLAYVLALGA PTMNFMVDET AAINSNKESQ QLVQKTYTLE KKEAMEEDEA
   781  PQHRDADIVQ GKGEAALWGE AGAVHEAPLR AWKPTAEQPE LAEEFTEKRE IPPGIERGAE
   841  GAAEAEGVRR LGEGGSDPIG QAAAKDAVGL SKDEAPEKQA LMLTVLETDK AASEGEQGLE
   901  KAVLANEAAA LNLEHLHEVA ALREAATSEE GEAEGGVAVS DVGESEEEAS IDLEDTGPME
   961  DTASKREDGS EEAILGGEEP AKERKEVMRT ETRLSPFTGE AEASRMQVSE GSPEEGSLAK
  1021  EAFLCKEDVE GEEMVTEAEA NREDDRKEIL PKELDLARER RKAERPKTSL RKTDSEREEV
  1081  TRANALKDED AFKEEQKLKA EEGETETEVR AEEETKAPPN EMGSDAENEA PVEASELSDN
  1141  PGLLGEDSLK ETVVPIFEAT PGFEKSLENI TALRKEGGGE RLSEARDTEH KDREELSSRE
  1201  NRALKEGHRQ DGEGALAAPE AEPAGKVQAP EGLIPATGQA EELAAKDHDS CAGLEGRAEG
  1261  QGGVDVVLRT QEAVAEEDPI MAEKFREEAV DEDPEEEEDK ECTLETEAMQ DRNSEGDGDM
  1321  EGEGNTQKNE GMGGGRVVAV EVLHGGGETA ETAAEEREVL AGSETAEEKT IANKASSFSD
  1381  VAEEETWHQQ DELVGKTAAA GKVVVEELAR SGEEVPAAEE MTVTYTTEAG VGTPGALERK
  1441  TSGLGQEQEE GSEGQEAATG SGDGRQETGA AEKFRLGLSR EGERELSPES LQAMATLPVK
  1501  PDFTETREKQ QHMVQGESET ADVSPNNVQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
fallopian tube: 16 nTPM
cerebral cortex: 10 nTPM
cervix: 5.1 nTPM
cerebellum: 3.8 nTPM
basal ganglia: 3.6 nTPM

Single-cell type

respiratory ciliated cells: 985 nCPM
fallopian tube ciliated cells: 555 nCPM
late spermatids: 533 nCPM
early spermatids: 320 nCPM
epididymal efferent duct ciliated cells: 297 nCPM
endometrial ciliated cells: 283 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 28 nTPM
basal ganglia: 23 nTPM
hippocampal formation: 23 nTPM
hypothalamus: 21 nTPM
white matter: 16 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glutamate-rich protein 3
Domain of unknown function DUF4590
Domain of unknown function (DUF4590)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH3 as an antibody target. Whether an autoantibody or antibody against ERICH3 could matter depends on whether native ERICH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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