Seroatlas · Human Serome Atlas

ERICH2

Glutamate-rich protein 2

Also known as: ERIC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1L162
Gene
ERICH2
Ensembl
ENSG00000204334
Chromosome
2
Canonical length
156 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

No narrative summary is available for ERICH2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>A1L162|ERICH2
     1  METVNEPETG EVSKDAVIVK QEKNNEYCLQ DIDDKLSESA EDDGEDDTND EDDDEDSNPK
    61  KNTQAPLELM AEFLRAEMAR EYQLAKKLCQ MILIYEPENP EAKEFFTLIE EMLLMEKTQN
   121  HEQDGENSDE DSSGESKGES DEELSDESSD EGEDGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
156 nTPM

Expression across tissuesHPA

Tissue

  • testis: 156 nTPM
  • choroid plexus: 45 nTPM
  • thyroid gland: 10 nTPM
  • lung: 9.1 nTPM
  • fallopian tube: 6.3 nTPM
  • parathyroid gland: 6.2 nTPM

Single-cell type

  • early spermatids: 2,878 nCPM
  • late primary spermatocytes: 1,069 nCPM
  • late spermatids: 358 nCPM
  • epididymal efferent duct ciliated cells: 132 nCPM
  • respiratory ciliated cells: 125 nCPM
  • alveolar cells type 2: 114 nCPM

Immune cell

  • gdT-cell: 0.7 nTPM
  • MAIT T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • hypothalamus: 12 nTPM
  • thalamus: 10 nTPM
  • basal ganglia: 9.7 nTPM
  • midbrain: 9 nTPM
  • cerebellum: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0.01
gnomAD missense Z
0.77

Protein domainsUniProt · Pfam · InterPro

  • Glutamate-rich protein 2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH2 as an antibody target. Whether an autoantibody or antibody against ERICH2 could matter depends on whether native ERICH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERICH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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