Seroatlas · Human Serome Atlas

ERICH1

Glutamate-rich protein 1

Also known as: ERIC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X53
Gene: ERICH1
Ensembl: ENSG00000104714
Chromosome: 8
Canonical length: 443 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

No narrative summary is available for ERICH1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q86X53|ERICH1
     1  MAAHRKHVFV EKVLQRLFPP VPSGQGKREP QTLAVQNPPK KVTSEKVSQK HAEPLTDTGS
    61  ETPTARRLYT ASGPPEGYVP CWPEPSSCGS PENASSGDDT EDQDPHDQPK RRRIRKHKSK
   121  KKFKNPNNVL IEQAELEKQQ SLLQEKSQRQ HTDGTTISKN KKRKLKKKQQ IKRKKAAGLA
   181  AKAAGVSFMY QPEDSSNEGE GVGEACEEDG VDTSEEDPTL AGEEDVKDTR EEDGADASEE
   241  DLTRARQEEG ADASEEDPTP AGEEDVKDAR EEDGVDTIEE DLTRAGEEDG KDTREEDGAD
   301  ASEEDPTWAG EEEGADSGEE DGADASEEDD TITNEKAHSI LNFLKSTQEM YFYDGVSRDA
   361  ASAALADAAE ELLDRLASHS MLPSDVSILY HMKTLLLLQD TERLKHALEM FPEHCTMPPD
   421  HARVISAFFS YWITHILPEK SSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERICH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
lymph node: 20 nTPM
kidney: 19 nTPM
appendix: 16 nTPM
adipose tissue: 15 nTPM
spleen: 15 nTPM

Single-cell type

hematopoietic stem cells: 352 nCPM
platelets: 311 nCPM
gonadotrophs: 230 nCPM
neutrophils: 205 nCPM
thymocytes: 182 nCPM
somatotrophs: 180 nCPM

Immune cell

classical monocyte: 33 nTPM
intermediate monocyte: 32 nTPM
neutrophil: 30 nTPM
non-classical monocyte: 30 nTPM
basophil: 25 nTPM
naive B-cell: 20 nTPM

Brain region

cerebral cortex: 18 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
choroid plexus: 15 nTPM
pons: 15 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -2.66
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Glutamate-rich protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERICH1 as an antibody target. Whether an autoantibody or antibody against ERICH1 could matter depends on whether native ERICH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERICH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERICH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...