Seroatlas · Human Serome Atlas

EPYC

Epiphycan

Also known as: DSPG3, EPYC_HUMAN, Pg-Lb, SLRR3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99645
Gene: EPYC
Ensembl: ENSG00000083782
Chromosome: 12
Canonical length: 322 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q99645|EPYC
     1  MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP VDKVEIEIAT
    61  VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE PEFTGVLGPH TNEDFPTCLL
   121  CTCISTTVYC DDHELDAIPP LPKNTAYFYS RFNRIKKINK NDFASLSDLK RIDLTSNLIS
   181  EIDEDAFRKL PQLRELVLRD NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH
   241  HLYLTDNNLD HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP
   301  INLSKTPQAY MCLPRLPVGS LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPYC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

placenta: 6 nTPM
endometrium: 0.8 nTPM
ovary: 0.4 nTPM
lymph node: 0.3 nTPM
adipose tissue: 0.2 nTPM
epididymis: 0.2 nTPM

Single-cell type

decidual stromal cells: 2.3 nCPM
fibro-adipogenic progenitors: 1.4 nCPM
late primary spermatocytes: 1.1 nCPM
late spermatids: 1.1 nCPM
fibroblasts: 1 nCPM
endometrial stromal cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glycosaminoglycan binding

Cellular components

extracellular matrix

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPYC as an antibody target. Whether an autoantibody or antibody against EPYC could matter depends on whether native EPYC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPYC is annotated as secreted, so native EPYC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EPYC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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