Seroatlas · Human Serome Atlas

EPN3

Epsin-3

Also known as: EPN3_HUMAN, FLJ20778, MGC129899

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H201
Gene: EPN3
Ensembl: ENSG00000049283
Chromosome: 17
Canonical length: 632 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Located in several cellular components, including clathrin-coated vesicle; cytoplasmic side of plasma membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q9H201|EPN3
     1  MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT VAFTEVMGML
    61  WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL YTIQTLKDFQ YIDRDGKDQG
   121  VNVREKVKQV MALLKDEERL RQERTHALKT KERMALEGIG IGSGQLGFSR RYGEDYSRSR
   181  GSPSSYNSSS SSPRYTSDLE QARPQTSGEE ELQLQLALAM SREEAEKPVP PASHRDEDLQ
   241  LQLALRLSRQ EHEKEVRSWQ GDGSPMANGA GAVVHHQRDR EPEREERKEE EKLKTSQSSI
   301  LDLADIFVPA LAPPSTHCSA DPWDIPGFRP NTEASGSSWG PSADPWSPIP SGTVLSRSQP
   361  WDLTPMLSSS EPWGRTPVLP AGPPTTDPWA LNSPHHKLPS TGADPWGASL ETSDTPGGAS
   421  TFDPFAKPPE STETKEGLEQ ALPSGKPSSP VELDLFGDPS PSSKQNGTKE PDALDLGILG
   481  EALTQPSKEA RACRTPESFL GPSASSLVNL DSLVKAPQVA KTRNPFLTGL SAPSPTNPFG
   541  AGEPGRPTLN QMRTGSPALG LAGGPVGAPL GSMTYSASLP LPLSSVPAGL TLPASVSVFP
   601  QAGAFAPQPL LPTPSSAGPR PPPPQTGTNP FL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

esophagus: 35 nTPM
stomach: 35 nTPM
skin: 30 nTPM
pancreas: 22 nTPM
parathyroid gland: 20 nTPM
vagina: 12 nTPM

Single-cell type

esophageal apical cells: 132 nCPM
cytotrophoblasts: 90 nCPM
parietal cells: 64 nCPM
esophageal suprabasal cells: 45 nCPM
migrating cytotrophoblasts: 45 nCPM
foveolar cells: 38 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 34 nTPM
thalamus: 34 nTPM
cerebellum: 19 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 18 nTPM
midbrain: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EPN3.

Disease | ImmuneIEDB

Conditions an epitope on EPN3 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

endocytosis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPN3 as an antibody target. Whether an autoantibody or antibody against EPN3 could matter depends on whether native EPN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EPN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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