Seroatlas · Human Serome Atlas

EPCIP

Exosomal polycystin-1-interacting protein

Also known as: B37, C21orf120, C21orf62, EPCIP_HUMAN, PRED81

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYP8
Gene: EPCIP
Ensembl: ENSG00000205929
Chromosome: 21
Canonical length: 219 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in mitocytosis. Located in extracellular exosome and migrasome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9NYP8|EPCIP
     1  MAPPSRHCLL LISTLGVFAL NCFTKGQKNS TLIFTRENTI RNCSCSADIR DCDYSLANLM
    61  CNCKTVLPLA VERTSYNGHL TIWFTDTSAL GHLLNFTLVQ DLKLSLCSTN TLPTEYLAIC
   121  GLKRLRINME AKHPFPEQSL LIHSGGDSDS REKPMWLHKG WQPCMYISFL DMALFNRDSA
   181  LKSYSIENVT SIANNFPDFS YFRTFPMPSN KSYVVTFIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPCIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 22 nTPM
ovary: 8.4 nTPM
epididymis: 7.9 nTPM
kidney: 6.5 nTPM
pituitary gland: 4.2 nTPM
pancreas: 3.8 nTPM

Single-cell type

choroid plexus epithelial cells: 119 nCPM
ependymal cells: 38 nCPM
loop of henle epithelial cells: 37 nCPM
renal collecting duct principal cells: 12 nCPM
other brain neurons: 11 nCPM
distal convoluted tubule cells: 11 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.5 nTPM
T-reg: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 42 nTPM
midbrain: 17 nTPM
white matter: 13 nTPM
hypothalamus: 12 nTPM
thalamus: 12 nTPM
medulla oblongata: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitocytosis

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Exosomal polycystin-1-interacting protein
Exosomal polycystin 1 interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPCIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PKD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPCIP as an antibody target. Whether an autoantibody or antibody against EPCIP could matter depends on whether native EPCIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPCIP is annotated as secreted, so native EPCIP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EPCIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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