Seroatlas · Human Serome Atlas

EP400P1

Putative EP400-like protein

Also known as: E400N_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZTU2
Gene: EP400P1
Canonical length: 488 aa

OverviewNCBI Gene

No narrative summary is available for EP400P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q6ZTU2|EP400P1
     1  MQHVSSSQSS QRHVQWPGAC PGAGEEQPAC SQPSLPLTLP SPSHQLQQLM VRGGPAGGQN
    61  MNVDLQGVGP GLQGSPQVTL APLPLPSPTS PGFQFSAQPR RFEHGSPSYI QVTSPLSQQV
   121  QTQSPTQPSP GPGQALQNVR AGAPGPGLGL CSSSPTGDFV DASVLVRQIS LSPSSGGHFV
   181  FQDGSGLTQI AQGAQVQLQH PGTPITVRER RPSQPHTQSG GTIHHLGPQS PAAAGGAGLQ
   241  PLASPSHITT ANLPPQISSI IQGQLVQQQQ VLQGPPLPRP LGFERTPGVL LPGAGGAAGF
   301  GMTSPPPPTS PSRTAVPPGL SSLPLTSVGN TGMKKVPKKL EEIPPASPEM AQMRKQCLDY
   361  HHQEMQALKE VFKEYLIELF FLQHFQGNMM DFLAFKERLY GPLQAYLRQN DLDIEEEEEE
   421  HFEVINDEVK VVARKHGQPG TPVAIATQLP PRTSAAFPAQ QQPLQQIHMG TPVPGDVNSI
   481  KMEASKRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EP400P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EP400P1 as an antibody target. Whether an autoantibody or antibody against EP400P1 could matter depends on whether native EP400P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EP400P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EP400P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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